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Extraction, structure and bioactivities of polysaccharide from root of Arctium lappa L.: A review

2024; Elsevier BV; Volume: 265; Linguagem: Inglês

10.1016/j.ijbiomac.2024.131035

1879-0003

Zheng Li, Zhiyuan Zhang, Jie Ding, Yuanyuan Li, Guiyun Cao, Lihao Zhu, Yifei Bian, Yuhong Liu,

Plant-derived Lignans Synthesis and Bioactivity

Arctium lappa L. root is a well-known Chinese medicine with high medicinal and food values. Arctium lappa L. root polysaccharide (ALP), as the main component and bioactive substance, has a variety of biological activities, including anti-inflammatory, antioxidant, hypoglycemic, hypolipidemic, antithrombotic, immunomodulatory activity and improvement of intestinal flora. The biological activities of polysaccharides are closely related to their structures, and different extraction and purification methods will yield different polysaccharide structures. As a kind of natural polysaccharide, ALP has a broad application prospect in drug carrier. In this paper, we reviewed the research progress on the extraction, purification, structural characterization, biological activities, structure-activity relationship and drug carrier application of ALP, in order to provide basic reference for the development and application of medical and health care value. At the same time, the shortcomings of ALP research are discussed in depth, and the potential development prospect and future research direction are prospected.