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Ductal carcinoma in situ of the breast, lessons learned after more than 10 years follow-up of a cohort of patients from a large western cancer centre

2024; Elsevier BV; Volume: 200; Linguagem: Inglês

10.1016/j.ejca.2024.113744

1879-0852

Marco Bernini, Dario Cassetti, C. Tommasi, Ilaria Gaggelli, Fabrizio Manetti, Gianfranco Gigliucci, L. Arlia, I. Meattini, Lorenzo Livi, Viola Salvestrini, L. Visani, G. Bicchierai, J. Nori Cucchiari, Diego De Benedetto, F. DiNaro, Simonetta Bianchi, Lorenzo Orzalesi,

Breast Cancer Treatment Studies

Background: Ductal carcinoma in situ (DCIS) of the breast is not necessarily precursor of invasive breast carcinoma (IBC). DCIS represents an intraductal lesion of the breast characterised by increased epithelial proliferation with cellular atypia not invading the basement membrane of the ductal lobular unit. Since the advent of widespread mammography has become clear that DCIS is a non-lethal problem and its main threat relates to the subsequent occurrence of IBC. The purpose of this study is to evaluate the characteristics of DCIS population, the rate of upgrading to IBC immediately at final pathology report after surgery and the rate of locoregional recurrence (LRR) either as DCIS or as invasive cancer after a long period of follow-up in a cohort of women submitted to surgery for DCIS in a large western cancer centre.