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Anticancer potential of nanoformulated extract of Passiflora incarnata leaves

2024; Elsevier BV; Volume: 57; Linguagem: Inglês

10.1016/j.bcab.2024.103109

1878-8181

Balasubramanian Deepika, Pragya Pallavi, Pemula Gowtham, Agnishwar Girigoswami, Koyeli Girigoswami,

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Cancer is one of the chief causes of death in the world, and there are various treatment modalities for cancer. Most of them cause adverse side effects, and to overcome these limitations, plant-based extracts are studied for their anticancer property. In the present study, we have extracted the ethanolic extract of Passiflora incarnata leaves and nanoformulated it with synthesized liposomes, characterized the nanoformulation using different photophysical tools, and compared the anticancer activity of the nanoformulated ethanolic extract and ethanolic extract of Passiflora incarnata leaves in various cancer cell lines. The nanoformulated ethanolic extract was found to be reduced in size and more stable than the ethanolic extract. We have found that the nanoformulated ethanolic extract isolated from Passiflora incarnata leaves induced necrosis in cancer cells and the nanoformulation has a dose-dependent effect on the inhibition of cancer cell growth. The nanoformulation of the Passiflora incarnata leaves ethanolic extract reduced the toxicity of normal cells compared to the ethanolic extract. Biocompatibility was tested by in vivo studies using a zebrafish model, where we found that both the ethanolic extract and nanoformulated ethanolic extract of Passiflora incarnata leaves did not induce any developmental deformity up to 100 μg/ml concentration, making the formulation biocompatible. Thus, the nanoformulated ethanolic extract of Passiflora incarnata leaves can be proposed as a potent anticancer agent.