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Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis

2024; Elsevier BV; Volume: 12; Issue: 5 Linguagem: Inglês

10.1016/s2213-8587(24)00040-8

2213-8595

Christina Reith, David Preiss, Lisa Blackwell, Jonathan Emberson, Enti Spata, Kelly Davies, Heather Halls, Charlie Harper, Lisa Holland, Kate Wilson, Alistair Roddick, Christopher P. Cannon, Robert Clarke, Helen M. Colhoun, Paul N. Durrington, Shinya Goto, G. A. Hitman, G. Kees Hovingh, J. Wouter Jukema, Wolfgang Köenig, Ian C. Marschner, Borislava Mihaylova, Connie B. Newman, Jeffrey L Probsfield, Paul M. Ridker, Marc S. Sabatine, Naveed Sattar, Gregory G. Schwartz, Luigi Tavazzi, Andrew Tonkin, Stella Trompet, Harvey D. White, Salim Yusuf, Jane Armitage, Anthony Keech, John Simes, Rory Collins, Colin Baigent, Elizabeth H Barnes, Jordan Fulcher, William G. Herrington, Adrienne Kirby, Rachel O’Connell, Pierre Amarenco, Hiroyuki Arashi, Philip J. Barter, D. J. Betteridge, Michael A. Blazing, Gerard J Blauw, Jackie Bosch, Louise Bowman, Eugene Braunwald, Richard Bulbulia, Robert Byington, Michael Clearfield, Stuart M. Cobbe, Björn Dahlöf, Barry R. Davis, James A. de Lemos, John R. Downs, Bengt Fellström, Marcus Flather, Ian Ford, Maria Grazia Franzosi, John A. Fuller, Curt D. Furberg, Robert J. Glynn, Uri Goldbourt, David Gordon, Antonio M. Gotto, Richard Grimm, A Gupta, C Hawkins, Richard Haynes, Hallvard Holdaas, Jemma C. Hopewell, Alan G. Jardine, John J.P. Kastelein, Sharon Kean, Patricia M. Kearney, George D. Kitas, John Kjekshus, Genell L. Knatterud, Robert H. Knopp, Michael J. Koren, Vera Krane, Martin Landray, John C. LaRosa, Roberto Latini, Eva Lonn, Donata Lucci, Jean MacFadyen, Peter W. Macfarlane, Stephen MacMahon, Aldo P. Maggioni, Roberto Marchioli, Lemuel A. Moyé, Sabina A. Murphy, Andrew Neil, Enrico Nicolis, Chris J. Packard, Sarah Parish, Terje R. Pedersen, Richard Peto, Marc A. Pfeffer, Neil R Poulter, Sara Pressel, Jeffrey L. Probstfield, Mahboob Rahman, Michele Robertson, Frank M. Sacks, Roland E. Schmieder, Patrick W. Serruys, Peter Sever, John Shaw, James Shepherd, Lara M. Simpson, Peter Sleight, Liam Smeeth, Jonathan A. Tobert, Gianni Tognoni, George Varigos, Christoph Wanner, Hans Wedel, Stephen E. Weis, K.M.A. Welch, John Wikstrand, Lars Wilhelmsen, Stephen D. Wiviott, Junichi Yamaguchi, Robin Young, Faı̈ez Zannad,

Health Systems, Economic Evaluations, Quality of Life

Previous meta-analyses of summary data from randomised controlled trials have shown that statin therapy increases the risk of diabetes, but less is known about the size or timing of this effect, or who is at greatest risk. We aimed to address these gaps in knowledge through analysis of individual participant data from large, long-term, randomised, double-blind trials of statin therapy.