Produção Nacional
Revisado por pares
An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoter
2024; Frontiers Media; Volume: 11; Linguagem: Inglês
10.3389/fnut.2024.1168715
ISSN2296-861X
AutoresTamires dos Santos Vieira, Flávia Vitorino Freitas, Luiz Cláudio Barreto Silva Neto, Aline Ribeiro Borçoi, Suzanny Oliveira Mendes, Amanda Sgrancio Olinda, Ivana Alece Arantes Moreno, Bárbara Risse Quaioto, Marcele Lorentz Mattos de Souza, Wagner Miranda Barbosa, Juliana Krüger Arpini, Bruna Pereira Sorroche, Júlia de Assis Pinheiro, Anderson Barros Archanjo, Joaquim Gasparini dos Santos, Lídia Maria Rebolho Batista Arantes, Daniela Rodrigues de Oliveira, Adriana Madeira Àlvares da Silva,
Tópico(s)Nutrition, Genetics, and Disease
ResumoBackground Dietary composition can modify gene expression, favoring the development of chronic diseases via epigenetic mechanisms. Objective Our study aimed to investigate the relationship between dietary patterns and NR3C1 gene methylation in users of the Brazilian Public Unified Health System (SUS). Methods We recruited 250 adult volunteers and evaluated their socioeconomic status, psychosocial characteristics, lifestyle, and anthropometrics. Peripheral blood was collected and evaluated for cortisol levels, glycemia, lipid profile, and insulin resistance; methylation of CpGs 40–47 of the 1F region of the NR3C1 gene was also measured. Factors associated with degree of methylation were evaluated using generalized linear models ( p < 0.05). Lifestyle variables and health variables were included as confounding factors. Results The findings of our cross-sectional study indicated an association between NR3C1 DNA methylation and intake of processed foods. We also observed relevant associations of average NR3C1 DNA across the segment analyzed, methylation in component 1 (40–43), and methylation in component 2 (44–47) with a pattern of consumption of industrialized products in relation to BMI, serum cortisol levels, and lipid profile. These results may indicate a relationship between methylation and metabolic changes related to the stress response. Conclusion These findings suggest an association of methylation and metabolic alterations with stress response. In addition, the present study highlights the significant role of diet quality as a stress-inducing factor that influences NR3C1 methylation. This relationship is further linked to changes in psychosocial factors, lifestyle choices, and cardiometabolic variables, including glucose levels, insulin resistance, and hyperlipidemia.
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