Portal de Periódicos da CAPES

Respiratory Syncytial Virus vs Influenza Virus Infection: Mortality and Morbidity Comparison Over 7 Epidemic Seasons in an Elderly Population

2024; Oxford University Press; Linguagem: Inglês

10.1093/infdis/jiae171

1537-6613

Caryn Recto, Slim Fourati, Mehdi Khellaf, Jean‐Michel Pawlotsky, Nicolas de Prost, Hadrien Diakonoff, Cristiano Donadio, Lydia Pouga, Christian de Tymowski, Christian Kassasseya,

Influenza Virus Research Studies

Abstract Background Respiratory syncytial virus (RSV) infection is gaining interest due to the recent development of vaccines but is still misdiagnosed in the elderly. The primary objective was to compare all-cause mortality at day 30. Secondary objectives were to compare clinical presentation and rates of consolidative pneumonia, hospitalization, and intensive care unit (ICU) admission. Methods A single-center retrospective study was conducted in a French university hospital during 7 epidemic seasons including 558 patients aged ≥75 years: 125 with RSV and 433 with influenza (median age, 84.8 years). Results Patients with RSV had more respiratory symptoms (wheezing, dyspnea) whereas patients with influenza had more general symptoms (fever, asthenia, myalgia). The following were higher in the RSV group: consolidative pneumonia (28.8% vs 17.2%, P = .004), hospitalization (83.2% vs 70%, P = .003), ICU admission (7.2% vs 3.0%, P = .034), and length of stay (median [IQR], 9 days [2–16] vs 5 days [0–12]; P = .002). Mortality rates at day 30 were comparable (9.6% vs 9.7%, P = .973). Conclusions This study included the largest cohort of patients infected with RSV aged >75 years documented in-depth thus far. RSV shares a comparable mortality rate with influenza but is associated with higher rates of consolidative pneumonia, hospitalization, ICU admissions, and extended hospital stays.