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Do Herbal Supplements and Probiotics Complement Antibiotics and Diet in the Management of SIBO? A Randomized Clinical Trial

2024; Multidisciplinary Digital Publishing Institute; Volume: 16; Issue: 7 Linguagem: Inglês

10.3390/nu16071083

2072-6643

Lucía Redondo‐Cuevas, Lucia Belloch, Vanesa Martín-Carbonell, A Nicolás, Iulia Alexandra, Laura Sanchís-Artero, Marina Ynfante, Michel Colmenares, María L. Mora, Ana Reyes Liebana, Beatríz Antequera, Juan Francisco Grau-Béjar, J R Molés, R. Sáinz de la Cuesta, Samuel Díaz, Noelia Sancho, Héctor Tomás, José Gonzalvo, Mercedes Jaén García, Eva Sánchez, Ana Garayoa, N. Fernández Moreno, Ana Gallén, Ernesto Cortés-Castell, Xavier Cortés,

Hydrogen's biological and therapeutic effects

Small intestinal bacterial overgrowth (SIBO) arises from dysbiosis in the small intestine, manifesting with abdominal symptoms. This study aims to assess the efficacy of combined antibiotic therapy, herbal supplements, probiotics, and dietary modifications in SIBO management. A total of 179 SIBO-diagnosed patients underwent clinical evaluation and breath testing. Patients were categorized into hydrogen (H2-SIBO) and methane (CH4-SIBO) groups. The control group received standard antibiotic therapy and a low-FODMAP diet, while the intervention group received additional herbal antibiotics, probiotics, and prebiotics. After treatment, both groups exhibited reduced gas levels, particularly in CH4-SIBO. Clinical remission rates were higher in the intervention group, especially in CH4-SIBO cases. Logistic regression analysis showed gas concentrations at diagnosis as significant predictors of treatment success. In conclusion, adjunctive herbal supplements and probiotics did not significantly impact gas levels, but showed potential for clinical improvement, especially in CH4-SIBO.