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Low-fluoride gels supplemented with nano-sized sodium trimetaphosphate reduce dentin erosive wear in vitro

2024; Elsevier BV; Volume: 163; Linguagem: Inglês

10.1016/j.archoralbio.2024.105973

1879-1506

Beatriz Díaz‐Fabregat, Alberto Carlos Botazzo Delbem, Wilmer Ramírez‐Carmona, Letícia Cabrera Capalbo, Liliana Carolina Baéz-Quintero, Annette Wiegand, Douglas Roberto Monteiro, Juliano Pelim Pessan,

Dental Health and Care Utilization

The study assessed the effect of low-fluoride gels supplemented with micrometric or nano-sized sodium trimetaphosphate (TMP) on dentin erosive wear in vitro. Bovine dentin blocks (n=154) were selected by surface microhardness and randomly allocated into seven groups (n=22/group), according to the gels: Placebo; 4,500 ppm F (4500 F); 9,000 ppm F (9000 F); 5% TMP microparticulate plus 4500 F (5TMPm+4500 F); 2.5% TMP nanoparticulate plus 4500 F (2.5TMPn+4500 F); 5% TMP nanoparticulate plus 4500 F (5TMPn+4500 F); and 12,300 ppm F acid gel (APF). All blocks were treated only once for 60 s and cyclically eroded (ERO, citric acid, 4×90 s/day) or eroded and brushed (4×15 s/day, five strokes/s, ERO+ABR) over five days (each subgroup n=11). Dentin wear and integrated hardness loss in depth (ΔKHN) were determined, and the data were submitted to two-way ANOVA, followed by Tukey's test, and Spearman's correlation (p<0.05). For ERO, all gels containing 4500 F supplemented with TMP significantly reduced dentin wear compared with their counterpart without TMP, reaching values similar to 9000 F. For ERO+ABR, 5TMPn+4500 F gel led to significantly lower wear than all its counterparts, reaching values similar to 9000 F and APF. As for ΔKHN, all gels containing TMP promoted superior protective effects compared with 4500 F, reaching values similar to 9000 F and APF under both challenges. A positive correlation between dentin wear and mineral content in depth was verified. Gels containing 4500 F supplemented with TMP significantly reduced dentin erosive wear compared with pure 4500 F, with additional benefit from the use of nanoparticles.