Molecular mechanism of α-synuclein aggregation on lipid membranes revealed
2024; Royal Society of Chemistry; Volume: 15; Issue: 19 Linguagem: Inglês
10.1039/d3sc05661a
ISSN2041-6539
AutoresAlexander J. Dear, Xiangyu Teng, Sarah R. Ball, J. Lewin, Robert I. Horne, Daniel Clow, Alisdair Stevenson, Natasha Harper, Kim Yahya, Xiaoting Yang, Suzanne Brewerton, John Thomson, Thomas C. T. Michaels, Sara Linse, Tuomas P. J. Knowles, Johnny Habchi, Georg Meisl,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoLipids are an important factor in the disease-associated aggregation of α-synuclein. Here we develop a kinetic model that allows the determination of mechanistic details and rate constants of this process.
Referência(s)