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Bacteria–Fungi Interactions in Multiple Sclerosis

2024; Multidisciplinary Digital Publishing Institute; Volume: 12; Issue: 5 Linguagem: Inglês

10.3390/microorganisms12050872

2076-2607

Miriam Gorostidi-Aicua, Iraia Reparaz, Ane Otaegui-Chivite, Koldo García, Leire Romarate, Amaya Álvarez de Arcaya, Idoia Mendiburu, Maialen Arruti, Tamara Castillo‐Triviño, Laura Moles, David Otaegui,

Mycorrhizal Fungi and Plant Interactions

Multiple sclerosis (MS) arises from a complex interplay between host genetic factors and environmental components, with the gut microbiota emerging as a key area of investigation. In the current study, we used ion torrent sequencing to delve into the bacteriome (bacterial microbiota) and mycobiome (fungal microbiota) of people with MS (pwMS), and compared them to healthy controls (HC). Through principal coordinate, diversity, and abundance analyses, as well as clustering and cross-kingdom microbial correlation assessments, we uncovered significant differences in the microbial profiles between pwMS and HC. Elevated levels of the fungus