Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial
2024; Nature Portfolio; Volume: 30; Issue: 7 Linguagem: Inglês
10.1038/s41591-024-02951-6
ISSN1546-170X
AutoresKate Bermingham, Inbar Linenberg, Lorenzo Polidori, Francesco Asnicar, Alberto Arrè, Jonathan Wolf, Fatema Badri, Hannah Bernard, Joan Capdevila Pujol, William J. Bulsiewicz, Christopher D. Gardner, José M. Ordovás, Richard Davies, George Hadjigeorgiou, Wendy L. Hall, Linda M. Delahanty, Ana M. Valdes, Nicola Segata, Tim D. Spector, Sarah Berry,
Tópico(s)Nutritional Studies and Diet
ResumoLarge variability exists in people's responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a personalized dietary program (PDP) versus general advice (control) on cardiometabolic health using a randomized clinical trial. The PDP used food characteristics, individual postprandial glucose and triglyceride (TG) responses to foods, microbiomes and health history, to produce personalized food scores in an 18-week app-based program. The control group received standard care dietary advice (US Department of Agriculture Guidelines for Americans, 2020-2025) using online resources, check-ins, video lessons and a leaflet. Primary outcomes were serum low-density lipoprotein cholesterol and TG concentrations at baseline and at 18 weeks. Participants (n = 347), aged 41-70 years and generally representative of the average US population, were randomized to the PDP (n = 177) or control (n = 170). Intention-to-treat analysis (n = 347) between groups showed significant reduction in TGs (mean difference = -0.13 mmol l
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