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Effect of Cangrelor on Infarct Size in ST-Segment–Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial (The PITRI Trial)

2024; Lippincott Williams & Wilkins; Volume: 150; Issue: 2 Linguagem: Inglês

10.1161/circulationaha.124.068938

1524-4539

Heerajnarain Bulluck, Jun Hua Chong, Jennifer Bryant, Annitha Annathurai, Ping Chai, Mervyn H.H. Chan, Ashish Chawla, Chee Yang Chin, Yiu‐Cho Chung, Fei Gao, Hee Hwa Ho, Andrew Fu Wah Ho, John Hoe, Syed Saqib Imran, Chi‐Hang Lee, Benji Lim, Soo Teik Lim, Swee Han Lim, Boon Wah Liew, Patrick Zhan-Yun Lim, Marcus Eng Hock Ong, Valeria Paradies, Xuan Ming Pung, Julian Cheong Kiat Tay, Lynette Teo, Boon Ping Ting, Aaron Wong, Evelyn Wong, Timothy Watson, Mark Y. Chan, Yeo Khung Keong, Jack Wei Chieh Tan, Derek J. Hausenloy, Jack W. Tan, Derek J. Hausenloy, C. Chi, Julian Tay, Pung Xuan Ming, Kamalesh Anbalakan, Keh Yann San, Kenneth Keen Yip Chew, Michelle MY Chan, Hong Rilong, Kui Swee Leng, Lim Soo Teik, Audry Lee, Felix Maverick Rubillar, James J. Cai, Jonathan Yap, W. Yan, Ho Kay Woon, Lim Fang Yi, Shen Xia Yen, Ruan Xucong, Yeo Khung Keong, Jun Hua Chong, Jennifer Bryant, Terrance Chua, Chee Yang Chin, Valeria Paradies, Aaron Wong, Leong Bahru, Tina Teo, Ru San Tan, Tang Hak Chiaw, Calvin Chin, F Ang, Min-Tun Kyaw, S. Priyalatha, J K Chua, Deborah Yip, Rosalind Lee, Katherina Oh, Ho Pei Yi, Leow Wanshan, Syamimi Atiqa Binte Rahmat, Gan Yar Chze, Derek J. Hausenloy, Fei Gao, Shi Yan Tan, Mervyn H.H. Chan, Lateef Fatimah, Andrew Fu Wah Ho, Wee Choon Peng Jeffrey, Swee Han Lim, Marcus Eng Hock Ong, Evelyn Wong, Kenneth Tan Boon Kiat, Venkataraman Anantharaman, Mark Y. Chan, Chi‐Hang Lee, Ping Chai, Low Adrian, Chan Koo Hui, Loh Poay Huan, Wang Yi-Ting Laureen, Chen Zhengfeng Jason, Mayank Dalakoti, Perryn Ng, Sia Ching Hui, Shaun Chook, Alfred Yip, Ng Zhe Yan, Andie Hartanto Djohan, Marie Houdmont, Nicholas Chew, Siew Jiamin, Faclin Ng, Lynette Teo, Ching Ching Ong, J. Song, Choong Kuang Low, Shalini Nair, Joseph F. Prabath, Hee‐Hwa Ho, Tasha Mahadi, Timothy Watson, Paul Jau Lueng Ong, Koo Xin Ni, Tony Chai Jun Hui, Ho Yue Ting, Khoo Zhi Lin Deanna, D Hyun, Li Ki Fung Cliff, Randal Low Jun Bang, T. Hor, Ng Ke Xuan Jessica, Chua Jia Min, Ong Wei Sheng Jonathan, Teoh Xuyan, Chiang Shu Qi Benita, Eran Sim Wen Jun, Ang An Shing, Quek Jia-ling Stephanie, Pang Yi, Bin Ahmad Hatib Muhammad Alimi, Lee Jin Hyun, Lim Shiane, Tan Chong Keat, Ng Shonda, John Hoe, Jack W. Tan, Chin Chee Yang, Fam Jian Ming, Siti Raudha, Annitha Annathurai, Boon Ping Ting, Ashish Chawla, Syed Saqib Imran, Patrick Zhan-Yun Lim, Alvin Tan, Benji Lim, Boon Wah Liew, Yong Thon Hon,

Coronary Interventions and Diagnostics

The administration of intravenous cangrelor at reperfusion achieves faster onset of platelet P2Y12 inhibition than oral ticagrelor and has been shown to reduce myocardial infarction (MI) size in the preclinical setting. We hypothesized that the administration of cangrelor at reperfusion will reduce MI size and prevent microvascular obstruction in patients with ST-segment-elevation MI undergoing primary percutaneous coronary intervention.