Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice
2024; American Association for the Advancement of Science; Volume: 16; Issue: 748 Linguagem: Inglês
10.1126/scitranslmed.adn0223
ISSN1946-6242
AutoresChristopher A. Cottrell, Xiaozhen Hu, Jeong Hyun Lee, Patrick Skog, Sai Luo, Claudia T. Flynn, Katherine McKenney, Jonathan Hurtado, Oleksandr Kalyuzhniy, Alessia Liguori, Jordan R. Willis, Elise Landais, Sebastian Raemisch, Xuejun Chen, Sabyasachi Baboo, Sunny Himansu, Jolene K. Diedrich, Hongying Duan, Cheng Cheng, Torben Schiffner, Daniel Bader, Daniel W. Kulp, Ryan Tingle, Erik Georgeson, Saman Eskandarzadeh, Nushin Alavi, Danny Lu, Troy Sincomb, Michael Kubitz, Tina-Marie Mullen, John R. Yates, James C. Paulson, John R. Mascola, Frederick W. Alt, Bryan Briney, Devin Sok, William R. Schief,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoA protective HIV vaccine will likely need to induce broadly neutralizing antibodies (bnAbs). Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with AS01
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