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Landscape of Invasive Fusariosis in Pediatric Cancer Patients: Results of a Multicenter Observational Study From Latin America

2024; Oxford University Press; Volume: 11; Issue: 6 Linguagem: Inglês

10.1093/ofid/ofae285

2328-8957

Fabianne Carlesse, Adriana Maria Paixão de Sousa da Silva, Jaques Sztajnbok, Nadia Litivinov, Karina Machado Peron, Marcelo Otsuka, Mariana Volpe Arnoni, M. Schirmer, Patrícia de Oliveira Costa, Ana Lucia Munhoz Cavalcanti de Albuquerque, Hugo Manuel Paz Morales, Eduardo López‐Medina, Carlos Andrés Portilla, Romina Valenzuela, Fabrizio Motta, Fábio de Araújo Motta, João Nóbrega de Almeida, Marı́a Elena Santolaya, Arnaldo Lopes Colombo,

Plant Pathogens and Fungal Diseases

Invasive fusariosis (IF) is a life-threatening opportunistic infection that affects vulnerable hosts. We conducted a multicenter and multinational retrospective study to characterize the natural history and clinical management of IF in pediatric cancer patients. We selected patients <18 years old who were sequentially hospitalized in 10 Latin American medical centers with a diagnosis of IF between 2002 and 2021. Data were collected using an electronic case report form complemented by a dictionary of terms. We assessed mortality rates at 30, 60, and 90 days. We collected data from 60 episodes of IF (median age, 9.8 years) that were mostly documented in patients with hematologic cancer (70%). Other risk conditions found were lymphopenia (80%), neutropenia (76.7%), and corticosteroid exposure (63.3%). IF was disseminated in 55.6% of patients. Skin lesions was present in 58.3% of our patients, followed by pulmonary involvement in 55%, sinusitis in 21.7%, bone/joint involvement in 6.7% and 1 case each of endocarditis and brain abscess. Positive blood and skin biopsy cultures were detected in 60% and 48.3% of cases, respectively.