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BIBTEX RIS

Skull base surgery for malignant tumors: The 2nd international collaborative study (1995–2015)

2024; Wiley; Volume: 46; Issue: 11 Linguagem: Inglês

10.1002/hed.27746

1097-0347

Jatin P. Shah, Helena Levyn, Cristina Valero, Dauren Adilbay, Alana Eagan, Junting Zheng, Mithat Gönen, Marc A. Cohen, Snehal G. Patel, Ian Ganly, Prathamesh Pai, Paolo Castelnuovo, Fang Ju Gao, Cesare Piazza, Piero Nicolai, Benedict Panizza, James Bowman, Catherine Barnett, Luiz Paulo Kowalski, Ronaldo Nunes Toledo, Dan M. Fliss, John DeAlmeida, Ian Witterick, Philippe Herman, Walter Fontanella, Gregorio Sánchez Aniceto, Şefik Hoşal, Serdar Özer, Subramania Iyer, Richard P. Harvey, C. René Leemans, Jan Hendrickx, Marcelo Figari, Luis Alejandro Boccalatte, Ken‐ichi Nibu, Peter Clarke, Catherine Rennie, Zhu Yi Ming, Cláudio Roberto Cernea, Sérgio Eduardo de Paiva Gonçalves, Rodney J. Schlosser, Fernando Luiz Dias, Zoukaa Sargi, Shahzada Ahmed, Wojciech Golusiński, Se‐Heon Kim, Shirley Y. Su, Shaan M. Raza, Franco DeMonte, Ehab Y. Hanna,

Bone Tumor Diagnosis and Treatments

Abstract Background The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide. Patients and methods A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes. Results The median age was 56 years (IQR 44–67). The open surgical approach was used in 55% ( n = 1680) of cases, endoscopic resection was performed in 36% ( n = 1087), and the combined approach in 9.6% ( n = 294). With a median follow‐up of 7.1 years, the 5‐year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor. Conclusion The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.