Produção Nacional
Revisado por pares
Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK‐air study
2024; Springer Science+Business Media; Volume: 14; Issue: 6 Linguagem: Inglês
10.1002/clt2.12358
ISSN2045-7022
AutoresBernardo Sousa‐Pinto, Gilles Louis, Rafael José Vieira, Heather J. Zar, Josep M. Antó, Rita Amaral, Ana Sá‐Sousa, Luisa Brussino, Giorgio Walter Canonica, Cláudia Chaves Loureiro, Ãlvaro A. Cruz, Bilun Gemicioğlu, Tari Haahtela, Maciej Kupczyk, Violeta Kvedarienė, Désirée Larenas‐Linnemann, N. Pham‐Thi, Francesca Puggioni, Frederico S. Regateiro, Jan Romantowski, J. Sastre, Nicola Scichilone, Luís Taborda‐Barata, Maria Teresa Ventura, Ioana Agache, Anna Bedbrook, Alida Benfante, Karl‐Christian Bergmann, Sinthia Bosnic‐Anticevich, Matteo Bonini, Louis‐Philippe Boulet, Guy Brusselle, Roland Buhl, Lorenzo Cecchi, D. Charpin, Elı́sio Costa, Stefano Del Giacco, Marek Jutel, Ludger Klimek, Piotr Kuna, Daniel Laune, Mika J. Mäkelä, Mário Morais‐Almeida, Rachel Nadif, Marek Niedoszytko, Nikolaos G. Papadopoulos, Alberto Papi, Oliver Pfaar, Daniela Rivero‐Yeverino, Nicolás Roche, Bolesław Samoliński, Mohamed H. Shamji, Aziz Sheikh, Charlotte Suppli Ulrik, Omar S. Usmani, Arūnas Valiulis, Arzu Yorgancıoğlu, Torsten Zuberbier, João Fonseca, Benoît Pétré, R. Louis, Jean Bousquet,
Tópico(s)Respiratory and Cough-Related Research
ResumoAbstract Rationale It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods In this cross‐sectional study, we assessed real‐world data using the MASK‐air ® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e‐DASTHMA score). Results were validated in a sample of patients with a physician‐established diagnosis of asthma. Measurement and Main Results We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e‐DASTHMA. Consistent results were observed when assessing patients with a physician‐made diagnosis of asthma. Conclusions Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
Referência(s)