Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

BRAF V600E mutation in ameloblastomas: Where are we?

2024; Wiley; Volume: 17; Issue: 4 Linguagem: Inglês

10.1111/ors.12905

1752-248X

Lucas Alves da Mota Santana, Lara Góis Floresta, Êmilly Victória Maciel Alves, Carlos Eduardo Mendonça Moura Costa, Bruno Bueno Zuzarte de Oliveira, Ronaldy Santana Santos, Eloia Emanuelly Dias Silva, Marina dos Santos Barreto, Marcos Antônio Lima dos Santos, Gopalsamy Rajiv Gandhi, Lysandro Pinto Borges, Idalísio Soares Aranha Neto, Cléverson Luciano Trento, Wilton Mitsunari Takeshita,

dental development and anomalies

Oral SurgeryEarly View LETTER TO THE EDITOR BRAF V600E mutation in ameloblastomas: Where are we? Lucas Alves da Mota Santana, Corresponding Author Lucas Alves da Mota Santana [email protected] orcid.org/0000-0002-8261-1504 School of Dentistry, Federal University of Sergipe (UFS), Aracaju, SE, Brazil School of Dentistry, Tiradentes University (UNIT), Aracaju, SE, Brazil Correspondence Lucas Alves da Mota Santana, School of Dentistry, Federal University of Sergipe (UFS), Rua Cláudio Batista, s/n, Santo Antônio, 49060102 Aracaju, SE, Brazil. Email: [email protected]Search for more papers by this authorLara Góis Floresta, Lara Góis Floresta orcid.org/0009-0009-2583-7687 School of Dentistry, Tiradentes University (UNIT), Aracaju, SE, BrazilSearch for more papers by this authorÊmilly Victória Maciel Alves, Êmilly Victória Maciel Alves School of Dentistry, Tiradentes University (UNIT), Aracaju, SE, BrazilSearch for more papers by this authorCarlos Eduardo Mendonça Moura Costa, Carlos Eduardo Mendonça Moura Costa School of Dentistry, Tiradentes University (UNIT), Aracaju, SE, BrazilSearch for more papers by this authorBruno Bueno Zuzarte de Oliveira, Bruno Bueno Zuzarte de Oliveira School of Dentistry, Tiradentes University (UNIT), Aracaju, SE, BrazilSearch for more papers by this authorRonaldy Santana Santos, Ronaldy Santana Santos School of Pharmacy, Federal University of Sergipe (UFS), Aracaju, SE, BrazilSearch for more papers by this authorEloia Emanuelly Dias Silva, Eloia Emanuelly Dias Silva School of Pharmacy, Federal University of Sergipe (UFS), Aracaju, SE, BrazilSearch for more papers by this authorMarina dos Santos Barreto, Marina dos Santos Barreto School of Pharmacy, Federal University of Sergipe (UFS), Aracaju, SE, BrazilSearch for more papers by this authorMarcos Antônio Lima dos Santos, Marcos Antônio Lima dos Santos Department of Stomatology, Faculty of Dentistry, University of São Paulo (USP), São Paulo, SP, BrazilSearch for more papers by this authorRajiv Gandhi Gopalsamy, Rajiv Gandhi Gopalsamy Division of Phytochemistry and Drug Design, Department of Biosciences, Rajagiri College of Social Sciences, Kochi, Kerala, IndiaSearch for more papers by this authorLysandro Pinto Borges, Lysandro Pinto Borges School of Pharmacy, Federal University of Sergipe (UFS), Aracaju, SE, BrazilSearch for more papers by this authorIdalísio Soares Aranha Neto, Idalísio Soares Aranha Neto Department of Dentistry, Catholic Pontifical University of Minas Gerais (PUC), Belo Horizonte, MG, BrazilSearch for more papers by this authorCleverson Luciano Trento, Cleverson Luciano Trento School of Dentistry, Federal University of Sergipe (UFS), Aracaju, SE, BrazilSearch for more papers by this authorWilton Mitsunari Takeshita, Wilton Mitsunari Takeshita Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, BrazilSearch for more papers by this author Lucas Alves da Mota Santana, Corresponding Author Lucas Alves da Mota Santana [email protected] orcid.org/0000-0002-8261-1504 School of Dentistry, Federal University of Sergipe (UFS), Aracaju, SE, Brazil School of Dentistry, Tiradentes University (UNIT), Aracaju, SE, Brazil Correspondence Lucas Alves da Mota Santana, School of Dentistry, Federal University of Sergipe (UFS), Rua Cláudio Batista, s/n, Santo Antônio, 49060102 Aracaju, SE, Brazil. Email: [email protected]Search for more papers by this authorLara Góis Floresta, Lara Góis Floresta orcid.org/0009-0009-2583-7687 School of Dentistry, Tiradentes University (UNIT), Aracaju, SE, BrazilSearch for more papers by this authorÊmilly Victória Maciel Alves, Êmilly Victória Maciel Alves School of Dentistry, Tiradentes University (UNIT), Aracaju, SE, BrazilSearch for more papers by this authorCarlos Eduardo Mendonça Moura Costa, Carlos Eduardo Mendonça Moura Costa School of Dentistry, Tiradentes University (UNIT), Aracaju, SE, BrazilSearch for more papers by this authorBruno Bueno Zuzarte de Oliveira, Bruno Bueno Zuzarte de Oliveira School of Dentistry, Tiradentes University (UNIT), Aracaju, SE, BrazilSearch for more papers by this authorRonaldy Santana Santos, Ronaldy Santana Santos School of Pharmacy, Federal University of Sergipe (UFS), Aracaju, SE, BrazilSearch for more papers by this authorEloia Emanuelly Dias Silva, Eloia Emanuelly Dias Silva School of Pharmacy, Federal University of Sergipe (UFS), Aracaju, SE, BrazilSearch for more papers by this authorMarina dos Santos Barreto, Marina dos Santos Barreto School of Pharmacy, Federal University of Sergipe (UFS), Aracaju, SE, BrazilSearch for more papers by this authorMarcos Antônio Lima dos Santos, Marcos Antônio Lima dos Santos Department of Stomatology, Faculty of Dentistry, University of São Paulo (USP), São Paulo, SP, BrazilSearch for more papers by this authorRajiv Gandhi Gopalsamy, Rajiv Gandhi Gopalsamy Division of Phytochemistry and Drug Design, Department of Biosciences, Rajagiri College of Social Sciences, Kochi, Kerala, IndiaSearch for more papers by this authorLysandro Pinto Borges, Lysandro Pinto Borges School of Pharmacy, Federal University of Sergipe (UFS), Aracaju, SE, BrazilSearch for more papers by this authorIdalísio Soares Aranha Neto, Idalísio Soares Aranha Neto Department of Dentistry, Catholic Pontifical University of Minas Gerais (PUC), Belo Horizonte, MG, BrazilSearch for more papers by this authorCleverson Luciano Trento, Cleverson Luciano Trento School of Dentistry, Federal University of Sergipe (UFS), Aracaju, SE, BrazilSearch for more papers by this authorWilton Mitsunari Takeshita, Wilton Mitsunari Takeshita Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, BrazilSearch for more papers by this author First published: 27 May 2024 https://doi.org/10.1111/ors.12905Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1Kelppe J, Thorén H, Ristimäki A, Haglund C, Sorsa T, Hagström J. BRAF V600E expression in ameloblastomas-a 36-patient cohort from Helsinki university hospital. Oral Dis. 2019; 25(4): 1169–1174. https://doi.org/10.1111/odi.13072 10.1111/odi.13072 PubMedWeb of Science®Google Scholar 2Derakhshan S, Aminishakib P, Karimi A, Saffar H, Abdollahi A, Mohammadpour H, et al. High frequency of BRAF V600E mutation in Iranian population ameloblastomas. Med Oral Patol Oral Cir Bucal. 2020; 25(4): e502–e507. https://doi.org/10.4317/medoral.23519 10.4317/medoral.23519 CASPubMedWeb of Science®Google Scholar 3Lapthanasupkul P, Laosuk T, Ruangvejvorachai P, Aittiwarapoj A, Kitkumthorn N. Frequency of BRAF V600E mutation in a group of Thai patients with ameloblastomas. Oral Surg Oral Med Oral Pathol Oral Radiol. 2021; 132(5): e180–e185. https://doi.org/10.1016/j.oooo.2020.06.002 10.1016/j.oooo.2020.06.002 PubMedGoogle Scholar 4Fregnani ER, Perez DE, Paes de Almeida O, et al. BRAF-V600E expression correlates with ameloblastoma aggressiveness. Histopathology. 2017; 70(3): 473–484. https://doi.org/10.1111/his.13095 10.1111/his.13095 PubMedWeb of Science®Google Scholar 5Abramson Z, Dayton OL, Drane WE, Mendenhall WM, Kaye FJ. Managing stage 4 ameloblastoma with dual BRAF/MEK inhibition: a case report with 8-year clinical follow-up. Oral Oncol. 2022; 128:105854. https://doi.org/10.1016/j.oraloncology.2022.105854 10.1016/j.oraloncology.2022.105854 CASPubMedWeb of Science®Google Scholar 6Ebeling M, Scheurer M, Sakkas A, Pietzka S, Schramm A, Wilde F. BRAF inhibitors in BRAF V600E-mutated ameloblastoma: systematic review of rare cases in the literature. Med Oncol. 2023; 40(6): 163. https://doi.org/10.1007/s12032-023-01993-z 10.1007/s12032-023-01993-z CASPubMedWeb of Science®Google Scholar 7Diniz MG, Gomes CC, Guimarães BV, et al. Assessment of BRAFV600E and SMOF412E mutations in epithelial odontogenic tumours. Tumour Biol. 2015; 36(7): 5649–5653. https://doi.org/10.1007/s13277-015-3238-0 10.1007/s13277-015-3238-0 CASPubMedGoogle Scholar 8Santana LADM, Santana EMR, Albuquerque-Júnior RLC, et al. Ameloblastoma shows nuclear BAP1 immunoexpression, independently of the BRAF V600E status. Oral Dis. 2021; 27(5): 1238–1242. https://doi.org/10.1111/odi.13644 10.1111/odi.13644 PubMedWeb of Science®Google Scholar 9Kurppa KJ, Catón J, Morgan PR, Ristimäki A, Ruhin B, Kellokoski J, et al. High frequency of BRAF V600E mutations in ameloblastoma. J Pathol. 2014; 232(5): 492–498. https://doi.org/10.1002/path.4317 10.1002/path.4317 CASPubMedWeb of Science®Google Scholar 10Sweeney RT, McClary AC, Myers BR, et al. Identification of recurrent SMO and BRAF mutations in ameloblastomas [published correction appears in Nat Genet. 2015 Jan;47(1):97]. Nat Genet. 2014; 46(7): 722–725. https://doi.org/10.1038/ng.2986 10.1038/ng.2986 CASPubMedWeb of Science®Google Scholar 11Pereira NB, Pereira KM, Coura BP, et al. BRAFV600E mutation in the diagnosis of unicystic ameloblastoma. J Oral Pathol Med. 2016; 45(10): 780–785. https://doi.org/10.1111/jop.12443 10.1111/jop.12443 CASPubMedWeb of Science®Google Scholar 12Soltani M, Tabatabaiefar MA, Mohsenifar Z, Pourreza MR, Moridnia A, Shariati L, et al. Genetic study of the BRAF gene reveals new variants and high frequency of the V600E mutation among Iranian ameloblastoma patients. J Oral Pathol Med. 2018; 47(1): 86–90. https://doi.org/10.1111/jop.12610 10.1111/jop.12610 CASPubMedWeb of Science®Google Scholar 13Shirsat PM, Bansal S, Prasad P, Desai RS. Low frequency of BRAF V600E immunoexpression in mandibular ameloblastomas: an institutional study. J Oral Maxillofac Pathol. 2018; 22(3): 353–359. https://doi.org/10.4103/jomfp.JOMFP_174_17 10.4103/jomfp.JOMFP_174_17 PubMedGoogle Scholar 14Heikinheimo K, Huhtala JM, Thiel A, Kurppa KJ, Heikinheimo H, Kovac M, et al. The mutational profile of Unicystic ameloblastoma. J Dent Res. 2019; 98(1): 54–60. https://doi.org/10.1177/0022034518798810 10.1177/0022034518798810 CASPubMedWeb of Science®Google Scholar 15Oh KY, Cho SD, Yoon HJ, Lee JI, Ahn SH, Hong SD. High prevalence of BRAF V600E mutations in Korean patients with ameloblastoma: clinicopathological significance and correlation with epithelial-mesenchymal transition. J Oral Pathol Med. 2019; 48(5): 413–420. https://doi.org/10.1111/jop.12851 10.1111/jop.12851 CASPubMedWeb of Science®Google Scholar 16Seki-Soda M, Sano T, Ito K, Yokoo S, Oyama T. An immunohistochemical and genetic study of BRAFV600E mutation in Japanese patients with ameloblastoma. Pathol Int. 2020; 70(4): 224–230. https://doi.org/10.1111/pin.12899 10.1111/pin.12899 CASPubMedWeb of Science®Google Scholar 17Owosho AA, Ladeji AM, Adebiyi KE, Olajide MA, Okoye ISI, Kehinde T, et al. BRAF V600E mutation-specific immunohistochemical analysis in ameloblastomas: a 44-patient cohort study from a single institution. Eur Arch Otorhinolaryngol. 2021; 278(8): 3065–3071. https://doi.org/10.1007/s00405-020-06491-w 10.1007/s00405-020-06491-w PubMedWeb of Science®Google Scholar 18Kokubun K, Yamamoto K, Akashi Y, Chujo T, Nakajima K, Matsuzaka K. Genetic study of BRAF V600E and SMO L412F mutations in Japanese patients with ameloblastoma. Int J Surg Pathol. 2022; 30(4): 378–384. https://doi.org/10.1177/10668969211064203 10.1177/10668969211064203 CASPubMedWeb of Science®Google Scholar 19Silveira FM, Schuch LF, Pereira-Prado V, Sicco E, Almeda-Ojeda O, Molina-Frechero N, et al. Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature. Med Oral Patol Oral Cir Bucal. 2024; 14. https://doi.org/10.4317/medoral.26493 10.4317/medoral.26493 Google Scholar 20Hussain MR, Baig M, Mohamoud HS, et al. BRAF gene: from human cancers to developmental syndromes. Saudi J Biol Sci. 2015; 22(4): 359–373. https://doi.org/10.1016/j.sjbs.2014.10.002 10.1016/j.sjbs.2014.10.002 CASPubMedWeb of Science®Google Scholar 21Bastos AU, Oler G, Nozima BH, Moysés RA, Cerutti JM. BRAF V600E and decreased NIS and TPO expression are associated with aggressiveness of a subgroup of papillary thyroid microcarcinoma. Eur J Endocrinol. 2015; 173(4): 525–540. https://doi.org/10.1530/EJE-15-0254 10.1530/EJE-15-0254 PubMedGoogle Scholar 22Abd Elmageed ZY, Moore RF, Tsumagari K, Lee MM, Sholl AB, Friedlander P, et al. Prognostic role of BRAFV600E cellular localization in melanoma. J Am Coll Surg. 2018; 226(4): 526–537. https://doi.org/10.1016/j.jamcollsurg.2017.12.040 10.1016/j.jamcollsurg.2017.12.040 PubMedGoogle Scholar 23Gomes CC, de Sousa SF, Gomez RS. Craniopharyngiomas and odontogenic tumors mimic normal odontogenesis and share genetic mutations, histopathologic features, and molecular pathways activation. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019; 127(3): 231–236. https://doi.org/10.1016/j.oooo.2018.11.004 10.1016/j.oooo.2018.11.004 PubMedWeb of Science®Google Scholar 24Oh KY, Cho SD, Yoon HJ, Lee JI, Hong SD. Discrepancy between immunohistochemistry and sequencing for BRAF V600E in odontogenic tumours: comparative analysis of two VE1 antibodies. J Oral Pathol Med. 2021; 50(1): 85–91. https://doi.org/10.1111/jop.13108 10.1111/jop.13108 CASPubMedWeb of Science®Google Scholar 25Bagchi A, Madaj Z, Engel KB, Guan P, Rohrer DC, Valley DR, et al. Impact of preanalytical factors on the measurement of tumor tissue biomarkers using immunohistochemistry. J Histochem Cytochem. 2021; 69(5): 297–320. https://doi.org/10.1369/0022155421995600 10.1369/0022155421995600 CASPubMedGoogle Scholar 26Anbinselvam A, Akinshipo AO, Adisa AO, et al. Comparison of diagnostic methods for detection of BRAFV600E mutation in ameloblastoma. J Oral Pathol Med. 2024; 53(1): 79–87. https://doi.org/10.1111/jop.13506 10.1111/jop.13506 CASPubMedGoogle Scholar 27do Canto AM, da Silva Marcelino BMR, Schussel JL, et al. Immunohistochemical analysis of BRAF V600E mutation in ameloblastomas. Clin Oral Investig. 2019; 23(2): 779–784. https://doi.org/10.1007/s00784-018-2494-y 10.1007/s00784-018-2494-y PubMedWeb of Science®Google Scholar 28Duarte-Andrade FF, Silva AMB, Vitório JG, Canuto GAB, Costa SFS, Diniz MG, et al. The importance of BRAF-V600E mutation to ameloblastoma metabolism. J Oral Pathol Med. 2019; 48(4): 307–314. https://doi.org/10.1111/jop.12839 10.1111/jop.12839 CASPubMedWeb of Science®Google Scholar 29Kaye FJ, Ivey AM, Drane WE, Mendenhall WM, Allan RW. Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma. J Natl Cancer Inst. 2014; 107(1):378. https://doi.org/10.1093/jnci/dju378 10.1093/jnci/dju378 PubMedGoogle Scholar 30Fernandes GS, Girardi DM, Bernardes JPG, Fonseca FP, Fregnani ER. Clinical benefit and radiological response with BRAF inhibitor in a patient with recurrent ameloblastoma harboring V600E mutation. BMC Cancer. 2018; 18(1): 887. https://doi.org/10.1186/s12885-018-4802-y 10.1186/s12885-018-4802-y PubMedWeb of Science®Google Scholar 31Burger MC, Ronellenfitsch MW, Lorenz NI, Wagner M, Voss M, Capper D, et al. Dabrafenib in patients with recurrent, BRAF V600E mutated malignant glioma and leptomeningeal disease. Oncol Rep. 2017; 38(6): 3291–3296. https://doi.org/10.3892/or.2017.6013 10.3892/or.2017.6013 CASPubMedGoogle Scholar 32Valpione S, Carlino MS, Mangana J, Mooradian MJ, McArthur G, Schadendorf D, et al. Rechallenge with BRAF-directed treatment in metastatic melanoma: a multi-institutional retrospective study [published correction appears in Eur J cancer. 2018 mar 13]. Eur J Cancer. 2018; 91: 116–124. https://doi.org/10.1016/j.ejca.2017.12.007 10.1016/j.ejca.2017.12.007 CASPubMedWeb of Science®Google Scholar 33Gomes CC, Diniz MG, Gomez RS. Progress towards personalized medicine for ameloblastoma. J Pathol. 2014; 232(5): 488–491. https://doi.org/10.1002/path.4331 10.1002/path.4331 CASPubMedWeb of Science®Google Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation