An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation
2024; Nature Portfolio; Volume: 15; Issue: 1 Linguagem: Inglês
10.1038/s41467-024-48748-6
ISSN2041-1723
AutoresJason Hou, Md Osman Goni Nayeem, Kian A. Caplan, Evan A. Ruesch, Albit Caban-Murillo, Ernesto Criado-Hidalgo, Sarah B. Ornellas, Brandon Williams, Ayeilla A. Pearce, Huseyin E. Dagdeviren, Michelle Surets, John A. White, Mikhail G. Shapiro, Fan Wang, Steve Ramirez, Canan Dağdeviren,
Tópico(s)Photoacoustic and Ultrasonic Imaging
ResumoPrecise neurostimulation can revolutionize therapies for neurological disorders. Electrode-based stimulation devices face challenges in achieving precise and consistent targeting due to the immune response and the limited penetration of electrical fields. Ultrasound can aid in energy propagation, but transcranial ultrasound stimulation in the deep brain has limited spatial resolution caused by bone and tissue scattering. Here, we report an implantable piezoelectric ultrasound stimulator (ImPULS) that generates an ultrasonic focal pressure of 100 kPa to modulate the activity of neurons. ImPULS is a fully-encapsulated, flexible piezoelectric micromachined ultrasound transducer that incorporates a biocompatible piezoceramic, potassium sodium niobate [(K,Na)NbO
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