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Upfront resection versus no resection of the primary tumor in patients with synchronous metastatic colorectal cancer: the randomized phase III CAIRO4 study conducted by the Dutch Colorectal Cancer Group and the Danish Colorectal Cancer Group

2024; Elsevier BV; Volume: 35; Issue: 9 Linguagem: Inglês

10.1016/j.annonc.2024.06.001

1569-8041

Dave E. W. van der Kruijssen, Sjoerd G. Elias, Peter M. van de Ven, Karlijn L. van Rooijen, Jorine ‘t Lam-Boer, Linda Mol, Cornelis J.A. Punt, Dirkje W. Sommeijer, Pieter J. Tanis, Jørn Dalsgaard Nielsen, M.K. Yilmaz, J.M.G.H. van Riel, D.K. Wasowiz-Kemps, O. J. L. Loosveld, George P. van der Schelling, J.W.B. de Groot, Henderik L. van Westreenen, Henrik Jakobsen, A.L. Fromm, Paul Hamberg, M. Verseveld, Claudia Jaensch, Gábor Liposits, Peter van Duijvendijk, Jamal Oulad Hadj, Joost A.B. van der Hoeven, Marija Trajkovic, Johannes H.W. de Wilt, M. Koopman, Jeroen Vincent, Johannes A. Wegdam, Brigitte C.M. Haberkorn, Erwin van der Harst, Mathijs P. Hendriks, Wilhelmina H. Schreurs, Huib A. Cense, Ron C. Rietbroek, Marie-José de Gier, Edwin A. van Breugel, Aad I. de Vos, Rebecca P. M. Brosens, Pascal G. Doornebosch, Felix E. de Jongh, Wouter J. Vles, Marien O. den Boer, Jeroen W. A. Leijtens, A. J. Gelderblom, Koen Peeters, Bart C. Kuenen, Bareld B. Pultrum, Joyce M. van Dodewaard-de Jong, Esther C. J. Consten, A.J. Yes van de Wouw, Joop Konsten, Ronald Hoekstra, Martijn F. Lutke Holzik, Allert H. Vos, M.J. van Hoogstraten, Nis H. Schlesinger, Geert-Jan Creemers, Ignace H. J. T. de Hingh, Monica L Kjaer, Lone N. Petersen, Michael Seiersen, Rahim Altaf, Hester van Cruijsen, Daniël A. Hess, Lobke L. van Leeuwen-Snoeks, Apollo Pronk, Coen I.M. Baeten, Wendy M. van der Deure, K. Bosscha, Heidi Schut, Wouter K. G. Leclercq, Lieke H. J. Simkens, Koen Reijnders, Kees van Arkel, W.M.U. Helma van Grevenstein, Anthony W. H. van de Ven, Ronald J.C.L.M. Vuylsteke, Philomeen Kuijer, Sandra D. Bakker, Hauwy Goei, Helgi H. Helgason, Gijs J.D. van Acker, Mehmet Temizkan, Marc W. A. van Tilburg, Michael F. Gerhards, Emile D. Kerver, Elske C. Gootjes, Peter Nieboer, Wim Bleeker, Gitta Bleeker,

Genetic factors in colorectal cancer

Upfront primary tumor resection (PTR) has been associated with longer overall survival (OS) in patients with synchronous unresectable metastatic colorectal cancer (mCRC) in retrospective analyses. The aim of the CAIRO4 study was to investigate whether the addition of upfront PTR to systemic therapy resulted in a survival benefit in patients with synchronous mCRC without severe symptoms of their primary tumor.