Portal de Periódicos da CAPES

Evaluation of Frequency of CMV Replication and Disease Complications Reveals New Cellular Defects and a Time Dependent Pattern in CVID Patients

2024; Springer Science+Business Media; Volume: 44; Issue: 6 Linguagem: Inglês

10.1007/s10875-024-01744-3

1573-2592

Luca Marri, Paola Contini, Federico Ivaldi, Chiara Schiavi, Ottavia Magnani, C. Vassallo, Andrea Guastalla, Noemi Traversone, Claudia Angelini, Genny Del Zotto, Andrea De Maria, Raffaele De Palma,

Parvovirus B19 Infection Studies

Common Variable Immunodeficiency (CVID) is characterized by hypogammaglobulinemia and failure of specific antibody production due to B-cell defects. However, studies have documented various T-cell abnormalities, potentially linked to viral complications. The frequency of Cytomegalovirus (CMV) replication in CVID cohorts is poorly studied. To address this gap in knowledge, we set up an observational study with the objectives of identifying CVID patients with active viraemia (CMV, Epstein-Barr virus (EBV)), evaluating potential correlations with immunophenotypic characteristics, clinical outcome, and the dynamic progression of clinical phenotypes over time.