Produção Nacional
Revisado por pares
Oropouche virus – The “Newest” invisible public enemy?
2024; Elsevier BV; Volume: 109; Linguagem: Inglês
10.1016/j.bmc.2024.117797
ISSN1464-3391
AutoresEdeildo Ferreira da Silva‐Júnior,
Tópico(s)Plant Virus Research Studies
ResumoThis perspective underscores the rising challenge posed by emerging diseases against the backdrop of modern advancements in global public health understanding. It particularly highlights the emergence of the Oropouche virus (OROV) as a significant global threat, detailing its transmission dynamics, symptoms, and epidemiological impact, with a focus on its historical and current manifestations. It further delves into the molecular aspects of OROV, elucidating its unique characteristics, lack of structural similarity with other arboviruses, and the limited progress in medicinal chemistry research. Still, it highlights notable studies on potential antiviral agents and the challenges in drug development, emphasizing the need for innovative approaches such as structure-based drug design (SBDD) and drug repurposing. Finally, it concludes with a call to action, urging increased attention and research focus on OROV to prevent potential future pandemics fueled by viral mutations.
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