Produção Nacional
Revisado por pares
TNF-α blockage prevents late neurological consequences of Zika virus infection in mice
2024; Elsevier BV; Volume: 471; Linguagem: Inglês
10.1016/j.bbr.2024.115114
ISSN1872-7549
AutoresRaíssa R. Christoff, Isabelle L. Liesner, Daniel Gavino-Leopoldino, Bruna Andrade, Beatriz Oliveira de Campos, Isabella Salgado, Felipe Simões-Lemos, Andrea T. Da Poian, Iranaia Assunção‐Miranda, Cláudia P. Figueiredo, Julia R. Clarke,
Tópico(s)Virology and Viral Diseases
ResumoZika virus (ZIKV) is a neurotropic Orthoflavivirus that causes a myriad of neurological manifestations in newborns exposed in uterus. Despite the devastating consequences of ZIKV on the developing brain, strategies to prevent or treat the consequences of viral infection are not yet available. We previously showed that short-term treatment with the TNF-α neutralizing monoclonal antibody. Infliximab could prevent seizures at acute and chronic stages of ZIKV infection, but had no impact on long-term cognitive and motor dysfunction. Due to the central role of inflammation in ZIKV-neuropathology, we hypothesized that prolonged treatment with the anti-TNF-α monoclonal antibody Infliximab could provide complete rescue of long-term behavioral deficits associated with neonatal ZIKV infection in mice. Here, neonatal (post-natal day 3) Swiss mice were submitted to subcutaneous (s.c.) injection of 10
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