Produção Nacional
Revisado por pares
Severe COVID-19 in pregnant women: Analysis of placental features and perinatal outcomes
2024; Oxford University Press; Linguagem: Inglês
10.1093/ajcp/aqae072
ISSN1943-7722
AutoresGelson Farias Arcos Júnior, Rossana Pulcineli Vieira Francisco, Beatriz Kill, Stela Verzinhasse Peres, Maria Augusta Bento Cicaroni Gibelli, Silvia Maria Ibidi, Werther Brunow de Carvalho, Angélica Bráz Simões, Maria de Lourdes Brizot, Regina Schultz, Mariana Azevedo Carvalho, Adriana Lippi Waissman, Aline Scalisse Bassi, Ana Claudia Rodrigues Lopes Amaral de Souza, Ana Cláudia Silva Farche, Ana Maria Kondo Igai, Carlos Eduardo do Nascimento Martins, Cristiane de Freitas Paganoti, Danielle Rodrigues Domingues, Fernanda Cristina Ferreira Mikami, Fernanda Spadotto Baptista, Jacqueline Kobayashi Cippiciani, Jéssica Gorrão Lopes Albertini, Joelma Queiróz Andrade, Juliana Ikeda Niigaki, Lucinda Cristina Pereira, Marco Aurélio Knippel Galletta, Mariana Yumi Miyadahira, Mariana Barbosa, Mônica Fairbanks de Barros, Sckarlet Ernandes Biancolin Garavazzo, Silvio Martinelli, Tiago Pedromônico Arrym, Úrsula Trovato Gomez, Veridiana Freire Franco,
Tópico(s)Maternal and fetal healthcare
ResumoAbstract Objectives Changes in placental features, such as maternal and fetal vascular malperfusion, are associated with SARS-CoV-2 infection. The anatomopathologic study of the placenta is crucial for understanding pregnancy and fetal complications. To that end, this study aimed to describe placental features and analyze the association between placental findings and perinatal outcomes in a cohort of pregnant women with severe COVID-19. Methods This nested study within a prospective cohort study consisted of 121 singleton pregnant women with a diagnosis of severe COVID-19. Placental pathologic findings were described, and the associations between severe COVID-19 and clinical parameters and perinatal outcomes were assessed. Results The prevalence of maternal vascular malperfusion was 52.1%, followed by fetal vascular malperfusion at 21.5%, ascending intrauterine infections at 11.6%, and inflammatory lesions at 11.6%. Other lesions were observed in 39.7% of the placentas examined. Inflammatory lesions were an independent factor (P = .042) in 5-minute Apgar scores below 7. Ascending infection was associated with fetal death (P = .027). Conclusions Maternal vascular malperfusion was the most prevalent placental feature in patients with severe COVID-19. Chorangiosis is associated with poor perinatal outcomes.
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