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BIBTEX RIS

Unravelling the Gut Microbiome Role in Cardiovascular Disease: A Systematic Review and a Meta-Analysis

2024; Multidisciplinary Digital Publishing Institute; Volume: 14; Issue: 6 Linguagem: Inglês

10.3390/biom14060731

ISSN

2218-273X

Autores

Diana Martins, Cláudia Silva, A. C. Ferreira, SARA BATISTA DOURADO, A. C. Albuquerque, Francisca Saraiva, Ana Beatriz Batista, Pedro Castro, Adelino Leite‐Moreira, António S. Barros, Isabel M. Miranda,

Tópico(s)

Metabolomics and Mass Spectrometry Studies

Resumo

A notable shift in understanding the human microbiome's influence on cardiovascular disease (CVD) is underway, although the causal association remains elusive. A systematic review and meta-analysis were conducted to synthesise current knowledge on microbial taxonomy and metabolite variations between healthy controls (HCs) and those with CVD. An extensive search encompassing three databases identified 67 relevant studies (2012-2023) covering CVD pathologies from 4707 reports. Metagenomic and metabolomic data, both qualitative and quantitative, were obtained. Analysis revealed substantial variability in microbial alpha and beta diversities. Moreover, specific changes in bacterial populations were shown, including increased

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