Unexpected discovery of CRP analytical interference: A case report
2024; Elsevier BV; Volume: 130; Linguagem: Inglês
10.1016/j.clinbiochem.2024.110781
ISSN1873-2933
AutoresVallauris Meslé, Eva Bories, Chloé Bost, Frédéric Alzieu, Thibaut Jamme,
Tópico(s)Biosimilars and Bioanalytical Methods
ResumoImmunoturbidimetric assays are sensitive techniques in clinical biology that may be subjected to matrix effects, hook effects or aspecific reactions. Among these, large quantities of immunoglobulins can distort the intensity of the detected signal. This study illustrates the deleterious effect of analytical interference on clinical patient management, and assesses the practical relevance of a recently proposed algorithm for interference investigation.
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