Sex-dependent differences in macaque brain mitochondria
2024; Elsevier BV; Volume: 1865; Issue: 4 Linguagem: Inglês
10.1016/j.bbabio.2024.149494
ISSN1879-2650
AutoresIvan Guerrero, Belem Yoval‐Sánchez, Csaba Konràd, Giovanni Manfredi, Ilka Wittig, Alexander Galkin,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoMitochondrial bioenergetics in females and males is different. However, whether mitochondria from male and female brains display differences in enzymes of oxidative phosphorylation remains unknown. Therefore, we characterized mitochondrial complexes from the brains of male and female macaques (Macaca mulatta). Cerebral tissue from male macaques exhibits elevated content and activity of mitochondrial complex I (NADH:ubiquinone oxidoreductase) and higher activity of complex II (succinate dehydrogenase) compared to females. No significant differences between sexes were found in the content of α-ketoglutarate dehydrogenase or in the activities of cytochrome c oxidase and F
Referência(s)