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Overexpression of BAG3 (Bcl2-associated athanogene 3) in serum and skin of patients with systemic sclerosis

2024; Springer Vienna; Linguagem: Inglês

10.55563/clinexprheumatol/ua07a2

1593-098X

Margot De Marco, Giuseppe Armentaro, Antonia Falco, Antonina Minniti, Anna Lisa Cammarota, Claudia Iannone, Anna Basile, Angela D’Ardia, Pio Zeppa, Liberato Marzullo, Alessandra Rosati, Claudio Vitali, Roberto Caporali, Nicoletta Del Papa,

Dermatologic Treatments and Research

BAG3 (Bcl2-associated athanogene3) is able to induce the transformation of cancer-associated fibroblasts to alpha smooth muscle actin (a-SMA) positive (+) myofibroblasts. In systemic sclerosis (SSc), a-SMA+ myofibroblasts also play an important role in the progression of fibrosis in the skin and involved internal organs. The aim of the study was to investigate whether BAG3 is overexpressed in SSc and may be a biomarker of fibrogenesis.