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Development of a subunit vaccine against the cholangiocarcinoma causing Opisthorchis viverrini: a computational approach

2024; Frontiers Media; Volume: 15; Linguagem: Inglês

10.3389/fimmu.2024.1281544

1664-3224

Mohibullah Shah, Farva Sitara, Asifa Sarfraz, Muhammad Shehroz, Tehreem Ul Wara, Asia Perveen, Najeeb Ullah, Aqal Zaman, Umar Nishan, Sarfraz Ahmed, Riaz Ullah, Essam A. Ali, Suvash Chandra Ojha,

Machine Learning in Bioinformatics

is the etiological agent of the disease opisthorchiasis and related cholangiocarcinoma (CCA). It infects fish-eating mammals and more than 10 million people in Southeast Asia suffered from opisthorchiasis with a high fatality rate. The only effective drug against this parasite is Praziquantel, which has significant side effects. Due to the lack of appropriate treatment options and the high death rate, there is a dire need to develop novel therapies against this pathogen. In this study, we designed a multi-epitope chimeric vaccine design against