Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton
2024; Cell Press; Volume: 43; Issue: 8 Linguagem: Inglês
10.1016/j.celrep.2024.114510
ISSN2639-1856
AutoresRyan D Mouery, Kimberly Lukasik, Carolyn Hsu, Thomas Bonacci, Derek L. Bolhuis, Xianxi Wang, Christine A. Mills, E Drew Toomer, Owen G Canterbury, Kevin Robertson, Timothy B. Branigan, Nicholas G. Brown, Laura E. Herring, Stephanie L. Gupton, Michael J. Emanuele,
Tópico(s)Microtubule and mitosis dynamics
ResumoUbiquitination is an essential regulator of cell division. The kinase Polo-like kinase 1 (PLK1) promotes protein degradation at G2/M phase through the E3 ubiquitin ligase Skp1-Cul1-F box (SCF)
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