Long-term outcomes of childhood-onset systemic lupus erythematosus
2024; Oxford University Press; Linguagem: Inglês
10.1093/rheumatology/keae344
ISSN1462-0332
AutoresAnne Mirguet, Florence A. Aeschlimann, I. Lemelle, R. Jaussaud, Paul Decker, T. Moulinet, S. Mohamed, Pierre Quartier, Michaël Hofer, Olivia Boyer, Alexandre Bélot, Aurélie Hummel, N. Costedoat‐Chalumeau, Brigitte Bader‐Meunier,
Tópico(s)Atherosclerosis and Cardiovascular Diseases
ResumoData on the long-term outcome of patients with childhood-onset Systemic Lupus Erythematosus (cSLE) are scarce. Aims of this study were to describe the long-term outcomes of cSLE and to identify factors associated with the development of damage and persistent disease activity. We conducted a retrospective multicentre study using data from the PEDIALUP registry of the Juvenile Inflammatory Rheumatism (JIR) cohort database. Demographic characteristics, clinical manifestations, laboratory, radiological, histological and treatment data were collected from medical records during follow-up. A total of 138 patients with cSLE, diagnosed between 1971 and 2015, were included. With a median follow-up of 15.4 [9.6-22.4] years, 51% of patients had a SLICC-Damage Index score ≥ 1 at last follow-up with the musculoskeletal, cutaneous, renal, neurological, and cardiovascular damage being the most common manifestations. The proportion of patients with a SLICC-DI score ≥ 1 increased significantly with the duration of the follow-up (p< 0.001). On multivariate analysis, duration of follow-up was associated with increased risk of cumulative damage (OR 1.08, 95% CI 1.01, 1.15, p= 0.035). At the last visit, 34% of patients still had active disease with a SLEDAI score of ≥ 6. On multivariate analysis, Sub-Saharan African ethnicity was associated with 7-fold increased odds of having active disease at the last visit compared with Caucasians (OR 7.44, 95% CI 2.24, 24.74, p= 0.0002). The prevalence of damage remains high in patients with cSLE even when the diagnosis of c-SLE has been made in the recent decades.
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