Produção Nacional
Revisado por pares
Selenium biomarkers and miR‐7‐5p in overweight/obese women
2024; Elsevier BV; Volume: 86; Linguagem: Inglês
10.1016/j.jtemb.2024.127499
ISSN1878-3252
AutoresHigor Paiva de Mendonça Alves, Graziela Biude Silva Duarte, Adriano Carlos de Souza, Leonam da Silva Pereira Batista, Marcelo Macedo Rogero, Fernando Barbosa, Sílvia Maria Franciscato Cozzolino, Raquel Costa Silva Dantas, Karina Costa, Bruna Zavarize Reis,
Tópico(s)Birth, Development, and Health
ResumoChronic low-grade inflammation and oxidative stress are pivotal contributors to the metabolic complications associated with obesity. Selenoprotein P (SELENOP) and glutathione peroxidase 1 (GPx1) are selenoproteins involved in the reduction of reactive oxygen species and pro-inflammatory cytokines levels. Nutritional epigenomics revealed the interaction of microRNAs and nutrients with an important impact on metabolic pathways involved in obesity. However, the knowledge regarding the influence of microRNA on selenium biomarkers and its impact on metabolic pathways related to obesity remains scarce. Thus, the aim of this study was to investigate the association of plasma miR-7-5p expression with selenium and inflammatory biomarkers in women with overweight/obesity.
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