Portal de Periódicos da CAPES

Population Pharmacokinetics of Dolutegravir in African Children: Results From the CHAPAS-4 Trial

2024; Oxford University Press; Volume: 13; Issue: 9 Linguagem: Inglês

10.1093/jpids/piae076

2048-7207

Hylke Waalewijn, Roeland E. Wasmann, Alasdair Bamford, Diana M. Gibb, Helen McIlleron, Angela Colbers, David M. Burger, Paolo Denti, Diana M. Gibb, Sarah Walker, Anna Turkova, Clare Shakeshaft, Moira J. Spyer, Margaret Thomason, Anna Griffiths, Lara N Monkiewicz, Sue Massingham, Alex J. Szubert, Alasdair Bamford, Katja Doerholt, Amanda Bigault, Nimisha Dudakia, Annabelle South, Nadine Van Looy, Carly Au, Hannah Sweeney, Cissy Kityo, Victor Musiime, Eva Natukunda, Esether Nambi, Diana Rutebarika Antonia, Rashida Nazzinda, Imelda Namyalo, Joan Nangiya, Lilian Nabeeta, Aidah Nakalyango, Lilian Kobusingye, Caroline Otike, W Namala, Phionah Ampaire, Ayesiga Edgar, Claire Nasaazi, Milly Ndigendawani, Paul Ociti, Priscilla Kyobutungi, Ritah Mbabazi, Phyllis Mwesigwa Rubondo, Juliet Ankunda, Mariam Naabalamba, Mary Nannungi, Alex K. Musiime, Faith Mbasani, Babu Enoch Louis, Josephine Namusanje, Denis Odoch, Edward Bagirigomwa, Eddie Rubanga, Disan Mulima, Paul Oronon, Eram David Williams, David Baliruno, Josephine Kobusingye, Agnes Uyungrwoth, Barbara Mukanza, Jimmy Obira Okello, Emily Ninsiima, Lutaro Ezra, Christine Nambi, Nansaigi Mangadalen, Musumba Sharif, Nobert B Serunjogi, O.P. Benedict Thomas, Abbas Lugemwa, Shafic Makumbi, Sharif Musumba, Edward Mawejje, Ibrahim Yawe, Linda Jovia Kyomuhendo, Mariam Kasozi, Rogers Ankunda, Samson kariisa, Christine Inyakuwa, Emily Ninsiima, Lorna Atwine, Beatrice Tumusiime, John Ahuura, Deogracious Tukwasibwe, Violet Nagasha, J Kukundakwe, Mariam Zahara Nakisekka, Ritah Winnie Nambejja, Mercy Tukamushaba, Rubinga Baker, Edridah Keminyeto, Barbara Ainebyoona, Sula Myalo, J Acen, Nicholas Jinta Wangwe, Ian Natuhurira, Gershom Kananura Natukunatsa, Veronica Mulenga, Chishala Chabala, J.C. Lungu, Monica Kapasa, Khonzya Zyambo, Kevin Zimba, Dorothy Zangata, Ellen Shingalili, N. Mumba, Nayunda kaonga, Mukumbi Kabesha, Oliver Mwenechanya, Terrence Chipoya, Friday Manakalanga, Stephen Malama, Daniel Chola, Bwendo Nduna, Mwate Mwamabazi, Kabwe Banda, B. Kabamba, Muleya Inambao, Pauline Mahy Mukandila, Mwizukanji Nachamba, Stella Himabala, Shadrick Ngosa, Davies Sondashi, Collins Banda, Mark Munyangabe, Grace Mbewe Ngoma, Sarah Chimfwembe, Mercy Lukonde Malasha, Mumba Kajimalwendo, Henry Musukwa, Shadrick Mumba, James Hakim, Mutsa Bwakura‐Dangarembizi, Kusum Nathoo, Taneal Kamuzungu, Ennie Chidziva, Joyline Bhiri, Joshua Choga, Hilda Mujuru, Godfrey Musoro, Vivian Mumbiro, Moses Chitsamatanga, Constantine Mutata, Rudo Zimunhu, Shepherd Mudzingwa, Secrecy Gondo, Columbus Moyo, Ruth Nhema, Kathryn Boyd, Farai Matimba, Vinie Kouamou, Richard Matarise, Zorodzai Tangwena, Taona Mudzviti, Allen Matubu, Alfred Kateta, Victor Chinembiri, Dorinda Mukura, Joy Chimanzi, Dorothy Murungu, Wendy Mapfumo, Pia Ngwaru, Lynette Chivere, Prosper Dube, Trust Mukanganiki, Sibusisiwe Weza, Tsitsi Gwenzi, S Mutsai, M Phiri, Makhosonke Ndlovu, Tapiwa Gwaze, Stuart Chitongo, Winisayi Njaravani, Sandra Musarurwa, Cleopatra Langa, Sue Tafeni, Wilbert Ishemunyoro, Nathalie Mudzimirema, Wedu Ndebele, Mary Nyathi, Grace Siziba, Getrude Tawodzera, Tracey Makuchete, Takudzwa Chidarura, Shingaidzo Murangandi, Lawrence Mafaro, Owen Chivima, Sifiso Dumani, Beaullar Mampondo, Constance Maphosa, Debra Mwale, Rangarirai Dhlamini, Thabani Sibanda, Nobukhosi Madubeko, Silibaziso Nyathi, Zibusiso Matiwaza, Sylvia Nabukenya, Harriet Tibakabikoba, Sarah Nakalanzi, Cynthia Williams, Precious Chandiwana, Winnie Gozhora, Benedictor Dube, Sylvia Mulambo, Hope Mwanyungwi, David Burger, Angela Colbers, Hylke Waalewijn, Lisanne A. H. Bevers, Shaghayegh Mohsenian-Naghani, Helen McIlleron, Jennifer Norman, Lubbe Wiesner, Roeland E. Wasmann, Paolo Denti, Lufina Tsirizani Galileya, Eva Natukunda, Victor Musiime, Phillipa Musoke, Paul Revill, Simon Walker, Adeodata Kekitiinwa, Angela Mushavi, Febby Banda Kawamya, Denis Tindyebwa, Hermione Lyall, Ian Weller, Tim Peto, Philippa Musoke, Margaret Siwale, R A Kambarami, Johanna Roth, Pauline Beattie,

Renal Transplantation Outcomes and Treatments

Abstract We characterized population pharmacokinetics in 42 African children receiving once-daily 25 mg (14 to <20 kg) or 50 mg (>20 kg) dolutegravir. Coadministration with emtricitabine and tenofovir alafenamide reduced dolutegravir bioavailability by 19.6% (95% confidence interval: 8.13%–30.8%) compared with zidovudine or abacavir with lamivudine. Nevertheless, concentrations remained above efficacy targets, confirming current dosing recommendations.