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Inflammatory Markers Predict Blood Neurofilament Light Chain Levels in Acute COVID-19 Patients

2024; Multidisciplinary Digital Publishing Institute; Volume: 25; Issue: 15 Linguagem: Inglês

10.3390/ijms25158259

1661-6596

Rebecca De Lorenzo, Nicola Ivan Lorè, Annamaria Finardi, Alessandra Mandelli, F. Calesella, Mariagrazia Palladini, Daniela María Cirillo, Cristina Tresoldi, Fabio Ciceri, Patrizia Rovere-Querini, Angelo A. Manfredi, Mario Gennaro Mazza, Francesco Benedetti, Roberto Furlan,

SARS-CoV-2 and COVID-19 Research

Acute coronavirus disease 2019 (COVID-19) is paralleled by a rise in the peripheral levels of neurofilament light chain (NfL), suggesting early nervous system damage. In a cohort of 103 COVID-19 patients, we studied the relationship between the NfL and peripheral inflammatory markers. We found that the NfL levels are significantly predicted by a panel of circulating cytokines/chemokines, including CRP, IL-4, IL-8, IL-9, Eotaxin, and MIP-1ß, which are highly up-regulated during COVID-19 and are associated with clinical outcomes. Our findings show that peripheral cytokines influence the plasma levels of the NfL, suggesting a potential role of the NfL as a marker of neuronal damage associated with COVID-19 inflammation.