Produção Nacional
Revisado por pares
Transitional photoperiod induces a mania‐like behavior in male mice
2024; Wiley; Volume: 60; Issue: 6 Linguagem: Inglês
10.1111/ejn.16498
ISSN1460-9568
AutoresMayara Rodrigues Barbosa, Ellyda Fernanda Lopes Costa, Daniel Gomes Coimbra, Vinícius Tenório Braga Cavalcante Pinto, Daniel Leite Góes Gitaí, Marcelo Duzzioni, Manuel Tomás Crespo, Diego A. Golombék, Juan José Chiesa, Patricia V. Agostino, Tiago Gomes de Andrade,
Tópico(s)Neuroendocrine regulation and behavior
ResumoAbstract This study aimed to investigate the behavioral responses and circadian rhythms of mice to both rapid and gradual increases in photoperiod, mimicking the transition from winter to summer, which is associated with a heightened prevalence of hospitalizations for mania and suicidal behavior. Behavioral tests were performed in C57BL/6 male mice exposed to a transitional photoperiod, from short to long durations. To determine if circadian rhythms are affected, we measured spontaneous locomotor activity and body temperature. Mice exhibited heightened exploratory and risk‐taking behaviors compared with equatorial and static long (16:8 h of light–dark cycle for several days) groups. These behaviors were prevented by lithium. Spontaneous locomotor activity and body temperature rhythms persisted and were effectively synchronized; however, the relative amplitude of activity and interdaily stability were diminished. Additionally, the animals displayed increased activity during the light phase. Photoperiodic transition modulates behavior and circadian rhythms, mirroring certain features observed in bipolar disorder patients. This study introduces an animal model for investigating mania‐like behavior induced by photoperiodic changes, offering potential insights for suicide prevention strategies and the management of mood disorders.
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