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REACT: a randomized trial to assess the efficacy and safety of clazosentan for preventing clinical deterioration due to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

2024; American Association of Neurological Surgeons; Linguagem: Inglês

10.3171/2024.4.jns232191

1933-0693

Stephan A. Mayer, Nicolas Bruder, Giuseppe Citerio, Luc Defreyne, Cécile Dubois, Rajiv Gupta, Randall T. Higashida, Angelina Marr, Thanh N. Nguyen, Sébastiên Roux, Martin Smrčka, Ramón Torné, E. François Aldrich, NULL AUTHOR_ID, Claudius Thomé, Andreas Gruber, Xavier Wittebole, Luc Defreyne, Jacques Créteur, J. van Loon, Didier Ledoux, Tim E. Darsaut, Michael Kelly, Gwynedd E. Pickett, Anthony M. Kaufmann, Ondřej Bradáč, Martin Smrčka, S Rehák, Tomáš Hrbáč, Martin Sameš, Vladimír Přibáň, Troels Halfeld Nielsen, Peter Birkeland, Antti Ronkainen, Justiina Huhtakangas, Jaakko Rinne, Timo Koivisto, J.C. Dumont, Pierre Simeone, Russell Chabanne, Anne‐Claire Lukaszewicz, Thomas Ritzenthaler, Vincent Degos, Vincent Costalat, Philippe Séguin, Vincent Legros, Lionel Calviere, Étienne Gayat, Bertrand Rozec, Manfred Westphal, Sylvia Bele, Andreas Unterberg, Maria Wostrack, Sebastian Brandner, Ilker Y. Eyüpoglu, Juergen Konczalla, Nils Hecht, Stefan Wolf, Philipp Dammann, Ansgar Berlis, Angelika Ehlert, Jan Leppert, Ralph König, Jan F. Cornelius, A. Petridis, Florian Geßler, Attila Lajgut, Pál Barzó, András Büki, Péter Tóth, S. Szabó, Yigal Shoshann, Leon Levi, Moshe Attia, Sagi Harnof, Marina Munari, Giuseppe Citerio, Sandra Rossi, Anselmo Caricato, Paweł Słoniewski, Przemysław Kunert, Maciej Śniegocki, Dariusz J. Jaskólski, Robert Juszkat, Javier Ibáñez, Alfonso Lagares, J.F. Alén, Fuat Arikan Abello, Andreu Gabarrós Canals, Ramón Torné, Jesús Morera Molina, Carlos Dominguez Alonso, Fabián Romero-Chala, Ola Nilsson, Johan Ljungqvist, Oscar Åneman, Johanna Eneling, Ajith J. Thomas, Christopher S. Ogilvy, Jesse Liu, Henry H. Woo, Nicholas C. Bambakidis, John Reavey‐Cantwell, Jan Claassen, Gary Steinberg, Eric Sauvageau, Ahmed Cheema, Bappaditya Ray, Jean Rodrigo Garcia, Masoom Desai, Thanh Nguyen, Ali Alaraj, Sepideh Amin‐Hanjani, Kadir Erkmen, Gregory J. Zipfel, Ciarán J. Powers, Hazem Shoirah, J Mocco, Paul Singh, François Aldrich, J. Marc Simard, Michael T. Froehler, Kevin M. Cockroft, William R. Freeman, Jia Romit,

Neurosurgical Procedures and Complications

Ischemic complications account for significant patient morbidity following aneurysmal subarachnoid hemorrhage (aSAH). The Prevention and Treatment of Vasospasm with Clazosentan (REACT) study was designed to assess the safety and efficacy of clazosentan, an endothelin receptor antagonist, in preventing clinical deterioration due to delayed cerebral ischemia (DCI) in patients with aSAH.