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Long-acting injectable antiretrovirals for HIV treatment in the ICONA cohort: physicians’ and nurses’ points of view

2024; Oxford University Press; Volume: 79; Issue: 10 Linguagem: Inglês

10.1093/jac/dkae273

1460-2091

Antonella Cingolani, A Tavelli, Sara De Benedittis, Ilaria Mastrorosa, Camilla Muccini, Teresa Bini, Anna Carraro, Michele Compagno, Maria Mazzitelli, Marta Guastavigna, Massimo Cernuschi, Carlo Torti, Andrea Antinori, Antonella d’Arminio Monforte, Antonella d’Arminio Monforte, Andrea Antinori, Spinello Antinori, Antonella Castagna, Roberto Cauda, Giovanni Di Perri, Enrico Girardi, Rosaria Iardino, Adriano Lazzarin, Giulia Marchetti, C Mussini, Eugenia Quirós-Roldán, Loredana Sarmati, Barbara Suligoi, F von Schloesser, P. Viale, Antonella d’Arminio Monforte, Andrea Antinori, Antonella Castagna, F Ceccherini-Silberstein, Antonella Cingolani, Alessandro Cozzi‐Lepri, Antonio Di Biagio, Enrico Girardi, Andrea Gori, Sergio Lo Caputo, G Marchetti, Franco Maggiolo, C Mussini, Massimo Puoti, Carlo Federico Perno, Carlo Torti, Andrea Antinori, Francesca Bai, Alessandra Bandera, Stefano Bonora, Andrea Calcagno, Diana Canetti, Antonella Castagna, F Ceccherini-Silberstein, A Cervo, Antonella Cingolani, Paola Cinque, Alessandro Cozzi‐Lepri, Antonella d’Arminio Monforte, Antonio Di Biagio, Roberta Gagliardini, Andrea Giacomelli, Enrico Girardi, Nicola Gianotti, Andrea Gori, Giovanni Guaraldi, Simone Lanini, Giuseppe Lapadula, Miriam Lichtner, Alessia Lai, Sergio Lo Caputo, Giordano Madeddu, Franco Maggiolo, Vincenzo Malagnino, G Marchetti, Annalisa Mondi, Valentina Mazzotta, C Mussini, Silvia Nozza, Carlo Federico Perno, Stefania Piconi, Carmela Pinnetti, Massimo Puoti, Eugenia Quirós-Roldán, Roberto Rossotti, Stefano Rusconi, Maria Mercedes Santoro, Annalisa Saracino, Loredana Sarmati, Vincenzo Spagnuolo, Nicola Squillace, Valentina Svicher, L Taramasso, Carlo Torti, Alessandra Vergori, Alessandro Cozzi‐Lepri, Sara De Benedittis, Iuri Fanti, M. Giotta, Cécilia Marelli, A Rodano’, A Tavelli, Massimo Cernuschi, L Cosmaro, A Perziano, Valeria Calvino, Danilo Russo, M Farinella, Nicoletta Policek, Virginia Negro, Matteo Augello, Silvia Carrara, Silvia Graziano, Gennaro Prota, S Truffa, Donatella Vincenti, Roberta Rovito, Andrea Giacometti, Andrea Costantini, V Barocci, Annalisa Saracino, Carmen Rita Santoro, Eugenio Milano, Laura Comi, Claudia Suardi, P. Viale, Leonardo Badia, Silvia Cretella, E M Erne, A Pieri, Eugenia Quirós-Roldán, Emanuele Focà, C Minardi, B Menzaghi, C Abeli, Luchino Chessa, Francesco Pes, Paolo Maggi, Loredana Alessio, Giuseppe Nunnari, Benedetto Maurizio Celesia, Jacopo Vecchiet, Katia Falasca, Angelo Pan, Sarah Dal Zoppo, Daniela Segala, Massimo Antonio Di Pietro, Cecilia Costa, Sergio Lo Caputo, Sergio Ferrara, Matteo Bassetti, Emanuele Pontali, Sophie Blanchi, Nicoletta Bobbio, Giovanni Mazzarello, Miriam Lichtner, Laura Fondaco, Stefania Piconi, Chiara Molteni, Stefano Rusconi, G Canavesi, G Pellicanò, G Marchetti, Spinello Antinori, Gloria Montenegro Rizzardini, Massimo Puoti, Antonella Castagna, Alessandra Bandera, Valeria Bono, Maria Vittoria Cossu, Andrea Giacomelli, Riccardo Lolatto, M C Moioli, Laura Pezzati, S Diotallevi, Camilla Tincati, C Mussini, M Menozzi, Paolo Bonfanti, Giuseppe Lapadula, Vincenzo Sangiovanni, Ivan Gentile, Vincenzo Esposito, Nicola Coppola, Francesco Maria Fusco, Giovanni Di Filippo, Vincent Rizzo, Nadia Sangiovanni, Salvatore Martini, Anna Maria Cattelan, D Leoni, Antonio Cascio, Marcello Trizzino, Daniela Francisci, Elisabetta Schiaroli, Giustino Parruti, Federica Sozio, D Messeri, Sara Irene Bonelli, C Lazzaretti, R Corsini, Andrea Antinori, Roberto Cauda, Claudio Maria Mastroianni, Loredana Sarmati, Alessandra Latini, Antonella Cingolani, Ilaria Mastrorosa, Silvia Lamonica, M Capozzi, Marta Camici, Marco Rivano Capparuccia, Giancarlo Iaiani, C Stingone, L Gianserra, Jessica Paulicelli, Maria Maddalena Plazzi, G d’Ettore, Marisa Fusto, I Coledan, Giordano Madeddu, Andrea De Vito, Massimiliano Fabbiani, Francesca Montagnani, Alfredo Franco‐Obregón, Rosario Vecchio, B M Pasticci, Giuliano Enzi, Giancarlo Orofino, Guido Calleri, Giovanni Di Perri, Stefano Bonora, Giacomo Accardo, Carlo Tascini, Alejandra Londero, Giuliana Battagin, S Nicolè, Giulio Starnini, Serena Dell’Isola,

HIV, Drug Use, Sexual Risk

Abstract Background Implementation level of long-acting injectable agents cabotegravir/rilpivirine (LAI CAB/RPV) for human immunodeficiency virus (HIV) treatment in Italy is still not known. The aim of this study is to identify the status of implementation of LAI CAB-RPV and its barriers. Materials and methods A cross-sectional online survey was conducted among infectious diseases (ID) physicians and nurses belonging to the ICONA network in Italy. Three validate 4-items measures were used: Acceptability of Intervention Measure (AIM), Intervention Appropriateness Measure (IAM) and Feasibility of Intervention Measure (FIM). Results Out of 61 ICONA centres, 38 (62%) completed the survey: 57.9% were academic centres, 42.1% were hospital-based. In total, 104 respondents were ID physicians (57.4%), 77 were nurses (42.5%); 4.5% of all PWH followed at the 38 centres started LAI CAB/RPV at time of study. Centres taking care of >1000 PWH reported 95% application of procedures for LA implementation, higher than other centres (P = 0.009). Mean score of AIM was (16.0, standard deviation, SD, 3.3), of IAM (16.0, SD 3.0) and FIM (16.0, SD 2.9). A linear correlation was found between AIM and the number of people with HIV who started LAI CAB/RPV (25–50 versus <25, coefficient of correlation [b] 2.57, 95%CI 0.91–4.60, P = 0.004), academic versus hospital-based centres (b −1.59, 95%CI −2.76–0.110044, P = 0.007) and the absence of preliminary systematic assessment of staff (b −1.98, 95%CI −3.31–0.65, P = 0.004). Implementation barriers were not significantly different according to the number of PWH/centre. Conclusions LAI CAB/RPV implementation was low, with a great variability according to centre size. Tailored and centre-specific interventions to address barriers and to optimize the LA treatment implementation should be designed.