Produção Nacional
Revisado por pares
Genetic, Clinical, Epidemiological, and Immunological Profiling of IgG Response Duration after SARS-CoV-2 Infection
2024; Multidisciplinary Digital Publishing Institute; Volume: 25; Issue: 16 Linguagem: Inglês
10.3390/ijms25168740
ISSN1661-6596
AutoresFlávia Póvoa da Costa, Kevin Matheus Lima de Sarges, Rosilene da Silva, Erika Ferreira dos Santos, Matheus Holanda do Nascimento, Alice Maciel Rodrigues, Marcos Henrique Damasceno Cantanhede, Fabíola Brasil Barbosa Rodrigues, Maria de Nazaré do Socorro de Almeida Viana, Mauro de Meira Leite, Camille Ferreira de Oliveira, Pablo Fabiano Moura das Neves, Gabriel dos Santos Pereira Neto, Mioni Thieli Figueiredo Magalhães de Brito, Andréa Luciana Soares da Silva, Daniele Freitas Henriques, Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão, Maria Alice Freitas Queiroz, Izaura Maria Vieira Cayres Vallinoto, Antônio Carlos Rosário Vallinoto, Giselle Maria Rachid Viana, Eduardo José Melo dos Santos,
Tópico(s)Immune Cell Function and Interaction
ResumoThe IgG response against SARS-CoV-2 infection can persist for over six months (long response; LR). However, among 30% of those infected, the duration can be as short as three months or less (short response; SR). The present study assembled serological data on the anti-SARS-CoV-2 IgG response duration of two previous studies and integrated these results with the plasmatic cytokine levels and genetic profile of 10 immune-relevant SNPs that were also previously published, along with the plasmatic total IgG, IgA, and IgM levels, allowing for the genetic, clinical, immunological, and epidemiological aspects of the post-COVID-19 IgG response duration to be understood. The SR was associated with previous mild acute COVID-19 and with an SNP (rs2228145) in
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