Produção Nacional
Revisado por pares
Eugenia pohliana leaves essential oil inhibits fungal virulence and restores antibiotic efficacy in multidrug‐resistant bacterial strains
2024; Wiley; Linguagem: Inglês
10.1002/cbdv.202401604
ISSN1612-1880
AutoresJosé Thyálisson da Costa Silva, Saulo Almeida de Menezes, Rafael Pereira da Cruz, Lilian Cortez Sombra Vandesmet, Maria Tereza dos Santos Correia, Márcia Vanusa da Silva, Raimundo Luíz Silva Pereira, Marcos Aurélio Figueirêdo dos Santos, Adrielle Rodrigues Costa, Viviane Bezerra da Silva, Maraiza Gregorio de Oliveira, José Walber Gonçalves Castro, Priscilla Augusta de Sousa Fernandes, Evandro G. da Silva Júnior, Henrique Douglas Melo Coutinho, Clara Mariana Gonçalves Lima, Maria Flaviana Bezerra Morais‐Braga, José Weverton Almeida‐Bezerra,
Tópico(s)Antifungal resistance and susceptibility
ResumoAbstract This study aims to investigate the essential oil from leaves of Eugenia pohliana (EOEP) in regard to its chemical composition, antimicrobial and drug‐enhancing activity, as well as the reduction of fungal virulence capacity. Chemical characterization using GC‐MS showed as major components the sesquiterpenes δ‐cadinene, Epi‐α‐Muurolol, and bicyclogermacrene. The results of antibacterial tests indicated that Staphylococcus aureus was more sensitive to EOEP, that also enhanced the efficacy of gentamicin, erythromycin, and norfloxacin. EOEP exhibited antifungal properties against Candida albicans , in addition to potentiating the effectiveness of fluconazole against Candida tropicalis . It showed anti‐virulence effects in all fungal strains. These findings underscore E. pohliana as a potential candidate for the prospection of novel therapeutic agents to treat infectious diseases caused by resistant microbes.
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