Hepatocyte-specific casein kinase 1 epsilon ablation ameliorates metabolic dysfunction-associated steatohepatitis by upregulating TRAF3 in mice.
2024; Elsevier BV; Volume: 194; Issue: 11 Linguagem: Inglês
10.1016/j.ajpath.2024.08.003
ISSN1525-2191
AutoresMwense Leya, Hyuneui Jeong, Daram Yang, Tien Huyen Ton Nu Bao, Prakash Raj Pandeya, Sang-Ik Oh, Yoon-Seok Roh, Jong-Won Kim, Bumseok Kim,
Tópico(s)FOXO transcription factor regulation
ResumoCasein kinase 1 epsilon (CK1ε), a member of the serine/threonine protein kinase family, is known to phosphorylate a broad range of substrates. However, its role in the development of chronic liver diseases remains elusive. This study aimed to investigate the role of CK1ε in the development and progression of metabolic dysfunction-associated steatohepatitis (MASH). Hepatocyte-specific CK1ε knockout (CK1ε
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