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Recomendaciones para la inmunización de pacientes con errores innatos de la inmunidad

2024; Sociedad Argentina de Pediatría; Volume: 123; Issue: 1 Linguagem: Inglês

10.5546/aap.2023-10308

1668-3501

María N Tahuil, Carolina Bouso, Agostina Llarens, Luciano Urdinez, Andrea Gómez Raccio, Daniela Di Giovanni, Lucía Spossito, Miguel Galicchio, Diana Liberatore, Víctor Skrie, Julio César Orellana, Elma Nievas, Lucia M Tarquini, Lorena Regairaz, Jesica Triguy, Sonia Peña, María C Ballester, Danila Labonia, Guadalupe Pérez, Ana L Tolín, Mariana Villa, Diana Cabanillas,

Intramuscular injections and effects

Inborn errors of immunity (IEI) are a heterogeneous group of hereditary disorders that affect in number and/or function different components of the immune system, resulting in an increased risk and severity of infections, autoimmune diseases, allergic manifestations, autoinflammation and malignancy. Inactivated vaccines are generally safe in these patients, but may be ineffective in some cases, due to difference in immunogenicity. However, live viral and bacterial vaccines may lead to disease, with high morbidity and mortality, so it is essential a previous immunological work-out. In this document, the Pediatric Immunology Work Group of the Sociedad Argentina de Pediatría summarizes recommendations about immunizations in patients with IEI, their household contacts, as well as in patients under immunosuppressive treatment and hematopoietic stem cell transplant recipients.