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Prognostic and Predictive Significance of Primary Tumor Localization and HER2 Expression in the Treatment of Patients with KRAS Wild-Type Metastatic Colorectal Cancer: Single-Centre Experience from Serbia

2024; Multidisciplinary Digital Publishing Institute; Volume: 14; Issue: 8 Linguagem: Inglês

10.3390/jpm14080879

2075-4426

Jelena Radić, Ivan Nikolić, Ivana Kolarov-Bjelobrk, Tijana Vasiljević, Aleksandar Djurić, Vladimir Vidović, Bojana Kožik,

Genetic factors in colorectal cancer

The treatment of patients with metastatic colorectal cancer (mCRC) is complex and is impacted by the location of the primary tumor (LPT). Our study aims to emphasize the importance of LPT as a prognostic and predictive marker as well as to examine the significance of HER2 overexpression in patients with mCRC, particularly in relation to the response to Epidermal Growth Factor Receptor Antibody treatment (anti-EGFR therapy). In this study, 181 patients with Kirsten RAS (KRAS) wild-type mCRC who received anti-EGFR therapy were included. Among them, 101 had left colon cancer (LCC) and 80 had right colon cancer (RCC). Results demonstrated that patients with KRAS wild-type LCC had better median overall survival (OS) (43 vs. 33 months,