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Early antibiotic de-escalation in patients with severe infections due to bloodstream infection by Enterobacterales: a post-hoc analysis of a prospective multicentre cohort

2024; Elsevier BV; Volume: 64; Issue: 5 Linguagem: Inglês

10.1016/j.ijantimicag.2024.107317

1872-7913

Francesc Escrihuela-Vidal, Zaira R. Palacios‐Baena, Josune Goikoetxea, Pérez Rodríguez, José María Reguera Iglesias, Jordi Pedragosa, Leticia Sánchez Gómez, Lucía Boix-Palop, Alberto Bahamonde Carrasco, Clara Natera-Kindelán, Jonathan Fernández-Suárez, A Jover, Alejandro Smithson Amat, Alfonso del Arco, Juan Manuel Sánchez‐Calvo, Andrés Martín-Aspas, Pedro María Martínez Pérez-Crespo, Inmaculada López-Hernández, Jesús Rodríguez‐Baño, Luis Eduardo López-Cortés, Pilar Retamar, José Bravo Ferrer, Marcos Guzmán García, David Vinuesa García, Isabel Gea-Lázaro, Isabel Fernández Natal, Antonio Sánchez-Porto, Inés Pérez‐Camacho, Eva León, Esperanza Merino, María Carmen Fariñas, Isabel Reche,

Sepsis Diagnosis and Treatment

Data about antibiotic de-escalation in sepsis associated with the bloodstream and caused by Enterobacterales are scarce. The objectives of this study are to identify factors associated with early de-escalation and to analyse the impact of de-escalation on mortality in patients with Enterobacterales bloodstream infection (BSI) with a Sequential Organ Failure Assessment (SOFA) score ≥ 2.