Portal de Periódicos da CAPES

Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis

2024; Nature Portfolio; Volume: 634; Issue: 8033 Linguagem: Inglês

10.1038/s41586-024-07993-x

1476-4687

Minoru Takaoka, Xiaohui Zhao, Hwee Ying Lim, Costan G. Magnussen, Owen Ang, Nadine Suffee, Patricia R. Schrank, Wei Siong Ong, Dimitrios Tsiantoulas, Felix Sommer, Sarajo K. Mohanta, James Harrison, Yaxing Meng, Ludivine Laurans, Feitong Wu, Yuning Lu, Leanne Masters, Stephen A. Newland, Laura Denti, Mingyang Hong, Mouna Chajadine, Markus Juonala, Juhani S. Koskinen, Mika Kähönen, Katja Pahkala, Suvi Rovio, Juha Mykkänen, Russell Thomson, Tsuneyasu Kaisho, Andreas J. R. Habenicht, Marc Clément, Alain Tedgui, Hafid Ait‐Oufella, Tian Zhao, Meritxell Nus, Christiana Ruhrberg, Soraya Taleb, Jesse W. Williams, Olli T. Raitakari, Véronique Angeli, Ziad Mallat,

Lipoproteins and Cardiovascular Health

Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk