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Lung Protective Mechanical Ventilation in Severe Acute Brain Injured Patients: A Multicenter, Randomized Clinical Trial (PROLABI)

2024; American Thoracic Society; Linguagem: Inglês

10.1164/rccm.202402-0375oc

1535-4970

Luciana Mascia, Vito Fanelli, Alice Mistretta, Matteo Filippini, Mattia Zanin, Maurizio Berardino, Anna Teresa Mazzeo, Anselmo Caricato, Massimo Antonelli, Francesco Della Corte, Francesca Grossi, Marina Munari, Massimiliano Caravello, Francesco Alessandri, Irene Cavalli, Mario Mezzapesa, Lucia Martina Silvestri, Marilena Casartelli Liviero, Paolo Zanatta, Paolo Pelosi, Giuseppe Citerio, Claudia Filippini, Paola Rucci, Frank Rasulo, Tommaso Tonetti,

Cardiac Arrest and Resuscitation

Lung protective strategies using low tidal volumes and moderate positive end expiratory pressures (PEEP) are considered best practice in critical care, but interventional trials have never been conducted in acutely brain-injured patients due to concerns about carbon dioxide control and effect of PEEP on cerebral hemodynamic.