The role of 2ʹ–5ʹ-oligoadenylate synthase-like protein (OASL1) in biliary and hepatotoxin-induced liver injury in mice
2024; Nature Portfolio; Volume: 14; Issue: 1 Linguagem: Inglês
10.1038/s41598-024-72465-1
ISSN2045-2322
AutoresMwense Leya, Daram Yang, Tien Huyen Ton Nu Bao, Hyuneui Jeong, Sang-Ik Oh, Jong‐Hoon Kim, Jong-Won Kim, Bumseok Kim,
Tópico(s)Liver Disease and Transplantation
ResumoFollowing an injury, the liver embarks on a process that drives the accumulation and reformation of the extracellular matrix, leading to hepatic fibrosis. Type I interferons (IFNs), including IFN-α and IFN-β, play a crucial role in averting chronic liver injury through the activation of IFN-stimulated genes (ISGs), which are instrumental in sculpting adaptive immunity. The role of 2'-5'-oligoadenylate synthase-like protein 1 (OASL1), an antiviral ISG, in the context of liver fibrosis remains to be elucidated. To elicit liver fibrosis, a diet containing 0.1% diethoxycarbonyl-1,4-dihydrocollidine (DDC) and carbon tetrachloride (CCl
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