Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes
2024; Nature Portfolio; Volume: 15; Issue: 1 Linguagem: Inglês
10.1038/s41467-024-52566-1
ISSN2041-1723
AutoresXiaomei Sun, Yanhong Wang, Fei Yuan, Yanan Zhang, Xun Kang, Jian Sun, Pengcheng Wang, Tengfei Lu, Fanny Sae Wang, Jinbao Gu, Jinglin Wang, Qianfeng Xia, Aihua Zheng, Zhen Zou,
Tópico(s)Microfinance and Financial Inclusion
ResumoThe main vectors of Zika virus (ZIKV) and dengue virus (DENV) are Aedes aegypti and Ae. albopictus, with Ae. aegypti being more competent. However, the underlying mechanisms remain unclear. Here, we find Ae. albopictus shows comparable vector competence to ZIKV/DENV with Ae. aegypti by blood-feeding after antibiotic treatment or intrathoracic injection. This suggests that midgut microbiota can influence vector competence. Enterobacter hormaechei_B17 (Eh_B17) is isolated from field-collected Ae. albopictus and conferred resistance to ZIKV/DENV infection in Ae. aegypti after gut-transplantation. Sphingosine, a metabolite secreted by Eh_B17, effectively suppresses ZIKV infection in both Ae. aegypti and cell cultures by blocking viral entry during the fusion step, with an IC
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