Designed endocytosis-inducing proteins degrade targets and amplify signals
2024; Nature Portfolio; Linguagem: Inglês
10.1038/s41586-024-07948-2
ISSN1476-4687
AutoresBuwei Huang, Mohamad H. Abedi, Green Ahn, Brian Coventry, Isaac Sappington, Cong Tang, Rong Wang, Thomas Schlichthaerle, Jason Z. Zhang, Yujia Wang, Inna Goreshnik, Ching Wen Chiu, Adam Chazin-Gray, Sidney Chan, Stacey Gerben, Analisa Murray, Shunzhi Wang, Jason O’Neill, Yi Li, Ronald Yeh, Ayesha Misquith, Anitra C. Wolf, Luke M. Tomasovic, Dan I. Piraner, Maria J Duran Gonzalez, Nathaniel R. Bennett, Preetham Venkatesh, Maggie Ahlrichs, Craig L. Dobbins, Wei Yang, Xinru Wang, Danny D. Sahtoe, Dionne Vafeados, Rubul Mout, Shirin Shivaei, Longxing Cao, Lauren Carter, Lance Stewart, Jamie B. Spangler, Kole T. Roybal, Per Greisen, Xiaochun Li, Gonçalo J. L. Bernardes, Carolyn R. Bertozzi, David Baker,
Tópico(s)Glycosylation and Glycoproteins Research
ResumoEndocytosis and lysosomal trafficking of cell surface receptors can be triggered by endogenous ligands. Therapeutic approaches such as lysosome-targeting chimaeras
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