Profile of inflammatory biomarkers in extreme conditions: Changes of serum amyloid A in a 7-week summer camp in Antarctica (<i>Short Communication</i>)
2024; Masaryk University; Volume: 14; Issue: 1 Linguagem: Inglês
10.5817/cpr2024-1-5
ISSN1805-0697
AutoresMichele Macedo Moraes, Leandro Borges, Thiago Teixeira Mendes, Elaine Hatanaka, Rosa Maria Esteves Arantes,
Tópico(s)Bone health and osteoporosis research
ResumoIsolated, confined, and extreme (ICE) conditions faced in Antarctica can influence immune system and inflammatory responses in humans. We evaluated the inflammatory biomarkers serum amyloid A (SAA), transforming growth factor-beta (TGF-β), and fatty acid-binding protein 2 (FABP2). Seven expeditioners took part in a 7-week Antarctic summer camp (Nelson Island) and were evaluated at Pre-Camp (i.e., at the beginning of the ship travel), Camp-Initial (i.e., 4th and 5th day in camp), Camp-Final (i.e., 45th – 46th day), and at the Post-Camp (on the ship on the return journey). Camping in Antarctica induced a bi-phasic change in SAA, with an increase found at Camp-Initial followed by a return to baseline levels. Such finding indicates a transient acute inflammation that does not imply a chronic inflammation condition in the long term.
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