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Involvement of Renin-Angiotensin system (RAS) components in mild traumatic brain injury

2024; Elsevier BV; Volume: 1846; Linguagem: Inglês

10.1016/j.brainres.2024.149266

1872-6240

Caroline Amaral Machado, Bruna da Silva Oliveira, João Luís Vieira Monteiro de Barros, Heliana de Barros Fernandes, Eliana Cristina de Brito Toscano, Lucas M. Kangussu, Pedro Pires Goulart Guimarães, Ana Cristina Simões e Silva, Antônio Lúcio Teixeira, Aline Silva de Miranda,

Traumatic Brain Injury Research

The Renin Angiotensin System (RAS) plays a pathophysiological role in traumatic brain injury (TBI) but the evidence of its involvement in mild TBI (mTBI) is still limited. We aimed at investigating the levels of components from both the classical and counter-regulatory axis of the RAS in a mTBI animal model. Mice with mTBI displayed enhanced ACE/Ang II/AT