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Potential In Vitro Antimelanoma Effect of the Essential Oil from Croton grewioides Baill.

2024; Wiley; Linguagem: Inglês

10.1002/cbdv.202401867

1612-1880

Camyla Caroliny Neves de Andrade, Ana Luíza de Oliveira Lopes, Sâmia Sousa Duarte, Fátima de Lourdes Assunção Araújo de Azevedo, Paulo Bruno Araújo Loureiro, Geraldo Moisés Wanderley Amorim, Adegildo Rolim de Abreu Júnior, Marcelo Sobral da Silva, Josean Fechine Tavares, Sócrates Golzio dos Santos, Juan Carlos Ramos Gonçalves, Marianna Vieira Sobral,

Insect Pest Control Strategies

Abstract Cancer is a group of diseases characterized by uncontrolled cell growth, invasive capacity, and metastatic potential. Despite the continual progress in cancer treatment, high toxicity and resistance to therapy remain recurring challenges. Croton grewioides Baill. is a plant from the brazilian semi‐arid region with significant pharmacological potential due to its reported antidiarrheal, antioxidant, and antitumor properties. This study evaluated the antitumor activity of the essential oil from C. grewioides leaves (CgEO) by in vitro assays. CgEO showed higher cytotoxicity in human melanoma cells (SK‐MEL‐28), with a 50 % inhibitory concentration (IC 50 ) of 70.0 μg/mL after 72 h, but with low toxicity in healthy keratinocytes (HaCaT). Additionally, it was suggested that the antitumor effect of CgEO is associated with the induction of apoptosis, cell cycle alterations, and combined antioxidant action mechanisms. In conclusion, CgEO exhibits antitumor activity with lower toxicity in non‐tumor cells.